Anal cancer Anal Cancer Risk factors
for anal cancer include certain sexually transmitted infections. Bleeding with bowel movements, pain, and sometimes itching around the anus are typical symptoms. A manual examination... read more ,
throat cancer
Mouth and Throat Cancer Mouth and throat cancers are cancers that originate on the lips, the roof, sides, or floor of the mouth, tongue, tonsils, or back of the throat. Mouth and throat cancers may look like open sores... read more
These disorders are caused by the human papillomavirus, which also causes genital warts. The HPV vaccine contains only certain parts of the virus. The vaccine does not contain any live virus and thus cannot cause HPV infection. There are three vaccines for HPV:
All three HPV vaccines protect against the two types of HPV (types 16 and 18) that cause about 70% of cervical cancers and 90% of anal cancers. The nine-valent vaccine and quadrivalent vaccine protect against the two types of HPV (types 6 and 11) that cause more than 90% of genital warts, in addition to protecting against types 16 and 18. Only the nine-valent vaccine and quadrivalent vaccine are recommended for boys and men. Only the nine-valent vaccine is currently available in the United States. The vaccine is recommended for
The injection site sometimes becomes sore, swollen, and red. No serious side effects have been reported. The following are some English-language resources that may be useful. Please note that THE MANUAL is not responsible for the content of these resources.
VIEW PROFESSIONAL VERSION  Copyright © 2022 Merck & Co., Inc., Rahway, NJ, USA and its affiliates. All rights reserved. Indian J Sex Transm Dis AIDS. 2009 Jan-Jun; 30(1): 51–52. A new vaccine against nine of the most harmful strains of human papillomavirus (HPV) is under study at the Medical College of Georgia. The vaccine, called nine-valent, is being compared with Gardasil, a quadrivalent vaccine already in the market that
works against the two most deadly HPV types. Gardasil, approved by the U.S. Food and Drug Administration in 2006, protects against HPV types 16 and 18, which cause about 70% of HPV-related cervical cancer cases, and types 6 and 11, which cause about 90% of genital wart cases. The new drug could prevent infection from those four types and five other cancer-causing types. Like Gardasil, the new vaccine contains proteins that form virus-like particles that assemble into a hollow sphere resembling
HPV's protective coating. Since the sphere lacks the actual viral DNA on the inside, it cannot cause HPV, but the body is tricked into making antibodies to protect against the real thing. ScienceDaily (Nov. 20, 2007) — A new vaccine against nine of the most harmful strains of human papillomavirus is under study at the Medical College of Georgia.
file:///E:/New%20HPV%20Vaccine%20Under%20Study.htm According to researchers the new HPV vaccine might cover all types of HPV and be given as a nasal spray. Researchers say
they have created a synthetic vaccine that can be delivered as a nasal spray for HPV - source of the most common sexually transmitted disease in the United States and a cause of cervical cancer. The experimental vaccine, tested so far just with mice, also offers protection against different strains of HPV. The existing vaccine for HPV, called Gardasil, protects against four strains of the virus responsible for about 70% of all cervical cancers. It requires three injections for full protection.
The advantages of the synthetic vaccine are that it can be synthesized as if it were a drug and, made chemically in the lab rather than having to use biological systems. A synthetic vaccine should also be cheaper. Using this approach, the vaccine could also be given nasally. In their experiments, Roden and his colleagues used a protein from one of the strains of HPV - HPV16 - to create a man-made vaccine in the laboratory. When the vaccine was given to mice by injection or as nasal spray, it
protected not only against HPV16, but also against another strain of the virus -HPV45. Steven Reinberg; New HPV Vaccine Promising in Mice. It might cover all types of HPV and be given as a nasal spray, researchers say, posted 4/15/08; health day; available on
file:///E:/New%20HPV%20Vaccine%20Promising%20in%20Mice.htm Impact of a quadrivalent HPV vaccine on infection and cervical disease
related to 10 non-vaccine HPV types (31, 33, 35, 39, 45, 51, 52, 56, 58, and 59) associated with more than 20% of cervical cancers was evaluated. Vaccination reduced the rate of HPV-31/33/45/52/58 infection by 17.7% and of cervical intraepithelial neoplasia (CIN) 1-3 or adenocarcinoma in situ (AIS) by 18.8%. Vaccination also reduced the rate of HPV-31/58/59-related CIN1-3/AIS by 26.0, 28.1, and 37.6%, respectively. Although a modest reduction in HPV-31/33/45/52/58-related CIN2 or worse was
observed, the estimated reduction was not statistically significant. These cross-protection results complement the vaccine's prophylactic efficacy against diseases associated with HPV-6, -11, -16, and -18. Wheeler et al. The impact of quadrivalent human papillomavirus (HPV; types 6, 11, 16, and 18) L1 virus-like particle vaccine on infection and disease due to oncogenic non vaccine HPV types in sexually active women aged 16-26 years; J Infect Dis. 2009 Apr 1;199(7):919-22.
VACCINE EFFECTIVE FOR OLDER WOMEN AND YOUNG MEN: STUDIESHPV infection typically occurs within a few years after a person becomes sexually active, so the vaccine is recommended at a young age. Gardasil is currently approved for girls and young women aged 9 to 26 years. Recent studies, however, indicate that the vaccine is also effective for older women and young men. As reported in the June 1, 2009 advance online edition of The Lancet, Nubia Muñoz from the National Institute of Cancer in Bogota, Columbia, and colleagues reported that the quadrivalent HPV vaccine is efficacious in women aged 24-45 years not infected with the relevant HPV types at enrolment. In men, anal-genital HPV infection can lead to genital warts and penile, perineal, perianal and anal neoplasia and cancer. In addition, male HPV infection contributes significantly to infection and subsequent cervical disease in women. The quadrivalent HPV vaccine is efficacious in reducing the burden of HPV 6/11/16/18-related external genital lesions and infection in young men aged 16-26 years naive to the relevant HPV type at baseline. Studies Show HPV Vaccine Is Effective for Older Women and Young available from Men http://www.hivandhepatitis.com/recent/2009/060909_e.html EDITOR'S NOTEGardasil (Merck's cervical cancer vaccine) is the first vaccine against HPV to be awarded World Health Organization (WHO) prequalification. It is a recombinant quadrivalent vaccine against HPV types 6,11,16 and 18 responsible for 70% of cervical cancer and 90% of genital warts. It is currently indicated for use in girls and young women 9through 26 years of age for the prevention of cervical, vulvar and vaginal cancers and warts In July, 2009, WHO approved another cervical cancer vaccine Cervarix made by GlaxoSmithKline. It protects against HPV 16 and 18. Cervarix is formulated with AS04, a proprietary adjuvant that boosts the immune system response for a longer period of time to HPV strains. In developing countries, HPV vaccination seems to be a distant dream due to high cost. FootnotesSource of Support: Nil, Conflict of Interest: None declared. Articles from Indian Journal of Sexually Transmitted Diseases and AIDS are provided here courtesy of Wolters Kluwer -- Medknow Publications What type of vaccine is Gardasil?Vaccine Composition
9-valent HPV vaccine (Gardasil-9 [23 pages] ) is a non-infectious recombinant vaccine prepared from the purified virus-like particles (VLPs) of the major capsid (L1) protein of HPV types 6, 11, 16, 18, 31, 33, 45, 52, and 58.
What is Gardasil 4 vaccine?Gardasil is a vaccine, licensed for use in June 2006, by the FDA. It targets four strains of human papillomavirus (HPV) -- HPV-6, 11, 16, and 18. HPV-16 and HPV-18 account for about 70% of all cervical cancers. HPV-6 and -11 cause about 90% of genital warts.
What strains of HPV does Gardasil cover?Since late 2016, only Gardasil-9 (9vHPV) is distributed in the United States. This vaccine protects against nine HPV types (6, 11, 16, 18, 31, 33, 45, 52, and 58).
Is Gardasil a live vaccine?How does the HPV vaccine work? The vaccine contains a simulation of the virus — not a live virus. It cannot cause cancer or HPV infection. The HPV vaccine stimulates the body to produce antibodies against HPV.
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Gardasil is a ________ vaccine that contains 4 different strains of the human papillomavirus.
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