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Criteria A 5+ symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure.
1. Depressed mood most of the day, nearly every day, as indicated by either subjective report or observation made by others.
Note: in children/adolescents can be irritable mood
2. Markedly diminished interest or pleasure in all, or almost all, activities most of the day, nearly every day (indicated by subjective account or observation).
3. Significant weight loss or weight gain (not dieting), or decrease or increase in appetite nearly every day.
Note: in children, consider failure to make expected weight gain.
4. Insomnia or hypersomnia nearly every day.
5. Psychomotor agitation/retardation nearly every day (can be observed by others).
6. Fatigue or loss of energy nearly every day.
7. Feelings of worthlessness or excessive or inappropriate guilt (may be delusional) nearly every day.
8. Diminished ability to think or concentrate, or indecisiveness, nearly every day.
9. Recurrent thoughts of death (not just fear of dying), recurrent suicidal ideation without a specific plan, or a suicide attempt or a specific plan for committing suicide.

Criteria B The symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of functioning.

Criteria C The episode is not attributable to the physiological effects of a substance or to another medical condition.
Note: Criteria A-C represent a major depressive episode
Note: Important to distinguish grief (e.g. loss of loved one) from a major depressive episode

Criteria D The occurrence of the major depressive episode is not better explained by schizoaffective disorder, schizophrenia, schizophreniform disorder, delusional disorder, or other specified and unspecified schizophrenia spectrum and other psychotic disorders.

Criteria E There has never been a manic episode or hypomanic episode

Note: This exclusion does not apply if all of the manic-like or hypomanic-like episodes are substance-induced or are attributable to the physiological effects of another medical condition.

Criteria (A) Distinct period of abnormally and persistently elevated, expansive or irritable mood lasting at least ONE WEEK and present most of day, nearly everyday (or any duration of hospitalization is necessary)

Criteria (B) During mood disturbance or increased energy or activity, THREE or more Sx (4 if the mood is only irritable) are present to significant degree and represent a noticeable change from usual Bx- (1) Inflated self-esteem or grandiosity, (2) Decreased need for sleep, (3) More talkative than usual or pressure to keep talking, (4) Flight of ideas or subjective experience that thoughts are racing, (5) Distractibility, (6) Increase in goal directed activity (Socially, work, school, or sexual) or psychomotor agitation (purposeless non-goal directed activity)

Criteria (C) Causes significant impairment in functioning or necessary hospitalization

Criteria (D) Not attributable to physiological effects of substances or medical condition

With anxious distress, With mixed features, With Rapid Cycling, With melancholic features, With Atypical features, With mood-congruent psychotic features, With mood-incongruent psychotic features, With catatonia, With peripartum onset, With seasonal pattern

SPECIFY Course: In partial remission or In full remission

SPECIFY severity: mild, moderate, severe

Criteria (A) Period of abnormally and persistently elevated, expansive, or irritable mood and abnormally and persistently increased activity or energy, lasting at least FOUR consecutive days and present most days, nearly every day

Criteria (B) During mood disturbance or increased energy or activity, THREE or more Sx (4 if the mood is only irritable) are present to significant degree and represent a noticeable change from usual Bx: (1) Inflated self-esteem or grandiosity (2) Decreased need for sleep (3) More talkative than usual or pressure to keep talking (4) Flight of ideas or subjective experience that thoughts are racing (5) Distractibility (6) Increase in goal directed activity (Socially, work, school, or sexual) or psychomotor agitation (purposeless non-goal directed activity) (7) Excessive involvement in activities that have high potential for painful consequences (unrestricted buying sprees, sexual indiscretions, or foolish business investments)

Criteria (C) Episode is associated with an unequivocal change in functioning that is uncharacteristic of the individual when not symptomatic

Criteria (D) Disturbance in mood and the change in functioning are observable by others

Criteria (E) Episode not severe enough to cause impairment or hospitalization. If any psychotic features, episode is by definition manic

Criteria (F) Not attributable to effects of substance

What is persistent depressive disorder?

Also called dysthymia, persistent depressive disorder is a long-term form of depression. In a comparison between persistent vs. major depressive disorder, they share symptoms like loss of interest in normal daily activities, hopelessness, lack of productivity, low self-esteem, and an overall feeling of inadequacy and emptiness.

What is severe severe depression?

severe depression. A condition characterized by one or more Major Depressive episodes without a history of Manic, Mixed, or Hypomanic Episodes. These Major Depressive Episodes are not due to a medical condition, medication, abused substance, or Psychosis. If Manic, Mixed, or Hypomanic Episodes develop, the diagnosis is changed to Bipolar Disorder.

What is major depressive disorder (MDD)?

Also known as depression and unipolar depression, major depressive disorder (MDD) is a mood disorder that causes persistent feelings of sadness and loss of interest that can interfere with a person’s day-to-day life as well as their relationships with others and performance at work, school, and home.

What is the difference between major depression and dysthymic disorder?

Major depression differs from dysthymic disorder. To be diagnosed with major depressive disorder, a person has to experience symptoms almost every day within two weeks, while a dysthymia diagnosis occurs in people who experience symptoms for at least two years.

How does Persistent depressive disorder compare to major depressive disorder?

PDD and MDD are two forms of depression that have similar symptoms and treatment methods. The main difference concerns the duration of symptoms. PDD symptoms last for at least 2 years, in adults, while people with MDD experience depressive episodes that are separated by at least 2 months.

What is the main difference between dysthymia and major depressive disorder?

Differences between dysthymia (PDD) and depression (MDD) As a result, the most significant difference between the two conditions is how long a person may experience symptoms. For a diagnosis of MDD, symptoms must last at least 2 weeks , and for a diagnosis of PDD, symptoms must have been present for at least 2 years .

Does persistent depressive disorder include major depressive episodes?

Most people with PDD will also have an episode of major depression at some point in their lives. Older people with PDD may have difficulty caring for themselves, signs of cognitive limitations, struggle with isolation, or have medical illnesses.