What type of immunoglobulins are involved in type I hypersensitivity quizlet?

Allergic reactions occur only in people who are sensitized by prior exposure to a specific allergen. Please identify the correct sequence of events that occur in a type I response.

1. The activated B cells proliferate into IgE-producing plasma cells and memory cells.
2. The Fc portion of the IgE binds to Fc receptors on either mast cells or basophils, so that the Fab sites of the antibodies can interact with a specific allergen.
3. Sensitization begins when the first contact with the allergen induces an antibody response—helper T cells activate naive B cells.
4. Cross-linking triggers the mast cell or basophil to undergo degranulation, a process that releases its inflammatory mediators.
5. On second exposure to the antigen, when adjacent IgE molecules on a mast cell or basophil bind to that antigen, the IgE molecules are cross-linked.
6. These inflammatory mediators can have a variety of effects associated with a type I allergy response.

A) 3, 4, 1, 2, 5, 6
B) 2, 3, 1, 4, 6, 5
C) 6, 4, 3, 2, 5, 1
D) 3, 1, 2, 5, 4, 6
E) 3, 1, 6, 5, 2, 4

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What type of immunoglobulins are involved in type I hypersensitivity?

Type I hypersensitivity is also known as an immediate reaction and involves immunoglobulin E (IgE) mediated release of antibodies against the soluble antigen. This results in mast cell degranulation and release of histamine and other inflammatory mediators.

Is IgG involved in type 1 hypersensitivity?

In type I hypersensitivity, B cells are stimulated (by CD4+ Th2 cells) to produce IgE antibodies specific to an antigen. The difference between a normal infectious immune response and a type 1 hypersensitivity response is that in type 1 hypersensitivity, the antibody is IgE instead of IgA, IgG, or IgM.

What type of hypersensitivity involves IgG IgM and IgA?

Type II hypersensitivity reaction refers to an antibody-mediated immune reaction in which antibodies (IgG or IgM) are directed against cellular or extracellular matrix antigens, resulting in cellular destruction, functional loss, or tissue damage.

What is an example of a Type 1 hypersensitivity reaction quizlet?

Anaphylaxis is an example of type I hypersensitivity reaction, which occurs rapidly and systemically. Anaphylaxis is due to the reaction of immunoglobulin E (IgE) antibodies on mast cells with antigen, resulting in the release of mediators, especially histamine, which causes the allergic reaction.