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The mutation will change all
subsequent amino acids in the TYRTYR protein, leading to nonfunctional TYRTYR protein. Individuals with this mutation will lack melanin in their hair, skin, and eyes and will not tan in response to UVUV radiation.
Without a functional TYRTYR enzyme to catalyze the first two steps of the melanin synthesis pathway, melanin will not be produced. Without melanin, individuals will not have a tanning response to UVUV radiation. Note that UVUV radiation exposure will still lead to the production of
α-MSHα-MSH in keratinocytes. The α-MSHα-MSH will then activate a signal transduction pathway in melanocytes, leading to the production of MITFMITF, which will activate theTYRTYR, TYR2TYR2, and TYR1TYR1 genes. However, the TYRTYR enzyme will still be nonfunctional because of the major frameshift mutation.
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Which is a possible result of a miRNA molecule binding to an mRNA molecule?
Binding of a specific miRNA to its target on an mRNA can inhibit its expression by a variety of mechanisms. Although the most common mechanism is translational repression as a result of miRNA binding to the 3'UTR of an mRNA, mechanisms involving mRNA degradation and destabilization have also been described.
How are genes regulated by miRNAs miRNAs bind to quizlet?
How do microRNAs (miRNAs) regulate genes? miRNAs bind to mRNA and prevent translation. What specific role does small interfering RNA (siRNA) have in the formation of heterochromatin? siRNA binds to enzyme complexes and guides them to targeted DNA.
Which of the following claims about the Tyr TRP2 and TRP1 mammalian genes is most likely to he accurate?
Which of the following claims about the TYR, TRP2, and TRP1 mammalian genes is most likely to be accurate? The TYRTYR, TRP2TRP2, and TRP1TRP1 genes may be located on different chromosomes but are activated by the same transcription factor. Keratinocytes do not express the MITFMITF gene.
What molecule do microRNAs bind to and what is the direct result of this binding?
What molecule do microRNAs bind to, and what is the direct result of this binding? A) microRNAs bind to messenger RNA, which inhibits translation.