References
Mann M, Jensen O: Proteomic analysis of post-translational modifications. Nat Biotech. 2003, 21: 255-261. 10.1038/nbt0303-255.
CAS Google Scholar
Wu R, Haas W, Dephoure N, Huttlin EL, Zhai B, Sowa ME, Gygi SP: A large-scale method to measure absolute protein phosphorylation stoichiometries. Nat Methods. 2011, 8: 677-683.
CAS PubMed PubMed Central Google Scholar
Butkinaree C, Park K, Hart GW: O-linked beta-N-acetylglucosamine (O-GlcNAc): Extensive crosstalk with phosphorylation to regulate signaling and transcription in response to nutrients and stress. Biochim Biophys Acta. 2010, 1800: 96-106.
CAS PubMed Google Scholar
Seo J, Jeong J, Kim YM, Hwang N, Paek E, Lee K-J: Strategy for comprehensive identification of post-translational modifications in cellular proteins, including low abundant modifications: application to glyceraldehyde-3-phosphate dehydrogenase. J Proteome Res. 2008, 7: 587-602.
CAS PubMed Google Scholar
Mikesh LM, Ueberheide B, Chi A, Coon JJ, Syka JEP, Shabanowitz J, Hunt DF: The utility of ETD mass spectrometry in proteomic analysis. Biochim Biophys Acta. 2006, 1764: 1811-1822.
CAS PubMed PubMed Central Google Scholar
White MY, Edwards AVG, Cordwell SJ, van Eyk JE: Mitochondria: a mirror into cellular dysfunction in heart disease. Prot Clin Appl. 2008, 2: 845-861. 10.1002/prca.200780135.
CAS Google Scholar
Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV: Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Cell Rep. 2012, 2: 419-431.
CAS PubMed PubMed Central Google Scholar
Bock T, Moest H, Omasits U, Dolski S, Lundberg E, Frei A, Hofmann A, Bausch-Fluck D, Jacobs A, Krayenbuehl N, Uhlen M, Aebersold R, Frei K, Wollscheid B: Proteomic analysis reveals drug accessible cell surface N-glycoproteins of primary and established glioblastoma cell lines. J Proteome Res. 2012, 11: 4885-4893.
CAS PubMed Google Scholar
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C: Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Mol Cell Proteomics. 2012, 11: 1578-1585.
PubMed PubMed Central Google Scholar
Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun. 2012, 3: 876-
PubMed PubMed Central Google Scholar
Kunz RC, McAllister FE, Rush J, Gygi SP: A high-throughput, multiplexed kinase assay using a benchtop orbitrap mass spectrometer to investigate the effect of kinase inhibitors on kinase signaling pathways. Anal Chem. 2012, 84: 6233-6239.
CAS PubMed Google Scholar
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP: Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell. 2011, 44: 325-340.
CAS PubMed PubMed Central Google Scholar
Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villén J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010, 143: 1174-1189.
CAS PubMed PubMed Central Google Scholar
Didangelos A, Stegemann C, Mayr M: The -omics era: proteomics and lipidomics in vascular research. Atherosclerosis. 2012, 221: 12-17.
CAS PubMed Google Scholar
Senis Y, Garcia A: Platelet proteomics: state of the art and future perspective. Methods Mol Biol. 2012, 788: 367-399.
CAS PubMed Google Scholar
Döring Y, Noels H, Weber C: The use of high-throughput technologies to investigate vascular inflammation and atherosclerosis. Arterioscler Thromb Vasc Biol. 2012, 32: 182-195.
PubMed Google Scholar
Di Michele M, Van Geet C, Freson K: Recent advances in platelet proteomics. Expert Rev Proteomics. 2012, 9: 451-466.
CAS PubMed Google Scholar
-
Johnson C, Tinti M, Wood NT, Campbell DG, Toth R, Dubois F, Geraghty KM, Wong BHC, Brown LJ, Tyler J, Gernez A, Chen S, Synowsky S, MacKintosh C: Visualization and biochemical analyses of the emerging mammalian 14-3-3-phosphoproteome. Mol Cell Proteomics. 2011, 10: M110.005751-
PubMed PubMed Central Google Scholar
Stone MD, Chen X, McGowan T, Bandhakavi S, Cheng B, Rhodus NL, Griffin TJ: Large-scale phosphoproteomics analysis of whole saliva reveals a distinct phosphorylation pattern. J Proteome Res. 2011, 10: 1728-1736.
CAS PubMed PubMed Central Google Scholar
Zhao X, León IR, Bak S, Mogensen M, Wrzesinski K, Højlund K, Jensen ON: Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes. Mol Cell Proteomics. 2011, 10: M110.000299-
PubMed Google Scholar
Rinschen MM, Yu M-J, Wang G, Boja ES, Hoffert JD, Pisitkun T, Knepper MA: Quantitative phosphoproteomic analysis reveals vasopressin V2-receptor-dependent signaling pathways in renal collecting duct cells. Proc Natl Acad Sci USA. 2010, 107: 3882-3887.
CAS PubMed PubMed Central Google Scholar
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006, 127: 635-648.
CAS PubMed Google Scholar
Manning G, Whyte D, Martinez R, Hunter T, Sudarsanam S: The protein kinase complement of the human genome. Science. 2002, 298: 1912-1934.
CAS PubMed Google Scholar
Chambers JW, Pachori A, Howard S, Iqbal S, LoGrasso PV: Inhibition of JNK mitochondrial localization and signaling is protective against ischemia-reperfusion injury in rats. J Biol Chem. 2013, 288: 4000-4011.
CAS PubMed Google Scholar
Das A, Salloum FN, Durrant D, Ockaili R, Kukreja RC: Rapamycin protects against myocardial ischemia-reperfusion injury through JAK2-STAT3 signaling pathway. J Mol Cell Cardiol. 2012, 53: 858-869.
CAS PubMed PubMed Central Google Scholar
Cheng Z, DiMichele LA, Hakim ZS, Rojas M, Mack CP, Taylor JM: Targeted focal adhesion kinase activation in cardiomyocytes protects the heart from ischemia/reperfusion injury. Arterioscler Thromb Vasc Biol. 2012, 32: 924-933.
CAS PubMed PubMed Central Google Scholar
Edwards AVG, Cordwell SJ, White MY: Phosphoproteomic profiling of the myocyte. Circ Cardiovasc Genet. 2011, 4: 575-
PubMed Google Scholar
Rose BA, Force T, Wang Y: Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale. Physiol Rev. 2010, 90: 1507-1546.
CAS PubMed Google Scholar
Kettenbach AN, Schweppe DK, Faherty BK, Pechenick D, Pletnev AA, Gerber SA: Quantitative phosphoproteomics identifies substrates and functional modules of Aurora and Polo-like kinase activities in mitotic cells. Sci Signal. 2011, 4: rs5-
CAS PubMed Google Scholar
Budas G, Costa HM, Ferreira JCB, Teixeira da Silva Ferreira AE, Perales J, Krieger JEE, Mochly-Rosen D, Schechtman D: Identification of εPKC targets during cardiac ischemic injury. Circ J. 2012, 76: 1476-1485.
CAS PubMed PubMed Central Google Scholar
Chou H-C, Chen Y-W, Lee T-R, Wu F-S, Chan H-T, Lyu P-C, Timms JF, Chan H-L: Proteomics study of oxidative stress and Src kinase inhibition in H9C2 cardiomyocytes: a cell model of heart ischemia-reperfusion injury and treatment. Free Radic Biol Med. 2010, 49: 96-108.
CAS PubMed Google Scholar
Cohen P: The regulation of protein function by multisite phosphorylation--a 25 year update. Trends Biochem Sci. 2000, 25: 596-601.
CAS PubMed Google Scholar
Moremen KW, Tiemeyer M, Nairn AV: Vertebrate protein glycosylation: diversity, synthesis and function. Nat Rev Mol Cell Biol. 2012, 13: 448-462.
CAS PubMed PubMed Central Google Scholar
Kornfeld S: A fascination with sugars. Mol Biol Cell. 2010, 21: 3773-3775.
CAS PubMed PubMed Central Google Scholar
Cordwell SJ, Thingholm TE: Technologies for plasma membrane proteomics. Proteomics. 2010, 10: 611-627.
CAS PubMed Google Scholar
Parker BL, Palmisano G, Edwards AVG, White MY, Engholm-Keller K, Lee A, Scott NE, Kolarich D, Hambly BD, Packer NH, Larsen MR, Cordwell SJ: Quantitative N-linked glycoproteomics of myocardial ischemia and reperfusion injury reveals early remodeling in the extracellular environment. Mol Cell Proteomics. 2011, 10: M110.006833-
PubMed PubMed Central Google Scholar
Ufret-Vincenty CA, Baro DJ, Lederer WJ, Rockman HA, Quinones LE, Santana LF: Role of sodium channel deglycosylation in the genesis of cardiac arrhythmias in heart failure. J Biol Chem. 2001, 276: 28197-28203.
CAS PubMed Google Scholar
Splawski I, Timothy KW, Tateyama M, Clancy CE, Malhotra A, Beggs AH, Cappuccio FP, Sagnella GA, Kass RS, Keating MT: Variant of SCN5A sodium channel implicated in risk of cardiac arrhythmia. Science. 2002, 297: 1333-1336.
CAS PubMed Google Scholar
Lönnqvist L, Karttunen L, Rantamäki T, Kielty C, Raghunath M, Peltonen L: A point mutation creating an extra N-glycosylation site in fibrillin-1 results in neonatal Marfan syndrome. Genomics. 1996, 36: 468-475.
PubMed Google Scholar
Lefeber DJ, de Brouwer APM, Morava E, Riemersma M, Schuurs-Hoeijmakers JHM, Absmanner B, Verrijp K, van den Akker WMR, Huijben K, Steenbergen G, van Reeuwijk J, Jozwiak A, Zucker N, Lorber A, Lammens M, Knopf C, van Bokhoven H, Grünewald S, Lehle L, Kapusta L, Mandel H, Wevers RA: Autosomal recessive dilated cardiomyopathy due to DOLK mutations results from abnormal dystroglycan O-mannosylation. PLoS Genet. 2011, 7: e1002427-
CAS PubMed PubMed Central Google Scholar
Hennet T: Diseases of glycosylation beyond classical congenital disorders of glycosylation. Biochim Biophys Acta. 2012, 1820: 1306-1317.
CAS PubMed Google Scholar
Larsen MR, Jensen SS, Jakobsen LA, Heegaard NHH: Exploring the sialiome using titanium dioxide chromatography and mass spectrometry. Mol Cell Proteomics. 2007, 6: 1778-1787.
CAS PubMed Google Scholar
McDonald CA, Yang JY, Marathe V, Yen T-Y, Macher BA: Combining results from lectin affinity chromatography and glycocapture approaches substantially improves the coverage of the glycoproteome. Mol Cell Proteomics. 2009, 8: 287-301.
CAS PubMed PubMed Central Google Scholar
Zhang H, Li X-J, Martin DB, Aebersold R: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. Nat Biotech. 2003, 21: 660-666. 10.1038/nbt827.
CAS Google Scholar
Palmisano G, Lendal SE, Engholm-Keller K, Leth-Larsen R, Parker BL, Larsen MR: Selective enrichment of sialic acid-containing glycopeptides using titanium dioxide chromatography with analysis by HILIC and mass spectrometry. Nat Protoc. 2010, 5: 1974-1982.
CAS PubMed Google Scholar
Jensen PH, Kolarich D, Packer NH: Mucin-type O-glycosylation--putting the pieces together. FEBS J. 2010, 277: 81-94.
CAS PubMed Google Scholar
Peng J, Jiang J, Wang W, Qi X, Sun X-L, Wu Q: Glycosylation and processing of pro-B-type natriuretic peptide in cardiomyocytes. Biochem Biophys Res Commun. 2011, 411: 593-598.
CAS PubMed PubMed Central Google Scholar
Chandrasekhar KD, Lvov A, Terrenoire C, Gao GY, Kass RS, Kobertz WR: O-glycosylation of the cardiac I(Ks) complex. J Physiol. 2011, 589: 3721-3730.
CAS PubMed PubMed Central Google Scholar
Wang Z, Udeshi ND, Slawson C, Compton PD, Sakabe K, Cheung WD, Shabanowitz J, Hunt DF, Hart GW: Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates cytokinesis. Sci Signal. 2010, 3: ra2-
PubMed PubMed Central Google Scholar
Zachara NE, O'Donnell N, Cheung WD, Mercer JJ, Marth JD, Hart GW: Dynamic O-GlcNAc modification of nucleocytoplasmic proteins in response to stress. A survival response of mammalian cells. J Biol Chem. 2004, 279: 30133-30142.
CAS PubMed Google Scholar
Zachara NE, Hart GW: Cell signaling, the essential role of O-GlcNAc!. Biochim Biophys Acta. 2006, 1761: 599-617.
CAS PubMed Google Scholar
Marsh SA, Chatham JC: The paradoxical world of protein O-GlcNAcylation: a novel effector of cardiovascular (dys)function. Cardiovasc Res. 2011, 89: 487-488.
CAS PubMed Google Scholar
Liu J, Marchase RB, Chatham JC: Increased O-GlcNAc levels during reperfusion lead to improved functional recovery and reduced calpain proteolysis. Am J Physiol Heart Circ Physiol. 2007, 293: H1391-H1399.
CAS PubMed PubMed Central Google Scholar
Fülöp N, Zhang Z, Marchase RB, Chatham JC: Glucosamine cardioprotection in perfused rat hearts associated with increased O-linked N-acetylglucosamine protein modification and altered p38 activation. Am J Physiol Heart Circ Physiol. 2007, 292: H2227-H2236.
PubMed PubMed Central Google Scholar
Hart GW, Slawson C, Ramirez-Correa G, Lagerlof O: Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease. Annu Rev Biochem. 2011, 80: 825-858.
CAS PubMed PubMed Central Google Scholar
Ngoh GA, Watson LJ, Facundo HT, Jones SP: Augmented O-GlcNAc signaling attenuates oxidative stress and calcium overload in cardiomyocytes. Amino Acids. 2011, 40: 895-911.
CAS PubMed Google Scholar
Marsh SA, Dell'Italia LJ, Chatham JC: Activation of the hexosamine biosynthesis pathway and protein O-GlcNAcylation modulate hypertrophic and cell signaling pathways in cardiomyocytes from diabetic mice. Amino Acids. 2011, 40: 819-828.
CAS PubMed Google Scholar
Hu Y, Belke D, Suarez J, Swanson E, Clark R, Hoshijima M, Dillmann WH: Adenovirus-mediated overexpression of O-GlcNAcase improves contractile function in the diabetic heart. Circ Res. 2005, 96: 1006-1013.
CAS PubMed Google Scholar
You L, Nie J, Sun W-J, Zheng Z-Q, Yang X-J: Lysine acetylation: enzymes, bromodomains and links to different diseases. Essays Biochem. 2012, 52: 1-12.
CAS PubMed Google Scholar
Guan K-L, Xiong Y: Regulation of intermediary metabolism by protein acetylation. Trends Biochem Sci. 2011, 36: 108-116.
CAS PubMed Google Scholar
Norris KL, Lee J-Y, Yao T-P: Acetylation goes global: the emergence of acetylation biology. Sci Signal. 2009, 2: pe76-
PubMed PubMed Central Google Scholar
-
Newman JC, He W, Verdin E: Mitochondrial protein acylation and intermediary metabolism: regulation by sirtuins and implications for metabolic disease. J Biol Chem. 2012, 287: 42436-42443.
CAS PubMed PubMed Central Google Scholar
Sack MN: The role of SIRT3 in mitochondrial homeostasis and cardiac adaptation to hypertrophy and aging. J Mol Cell Cardiol. 2012, 52: 520-525.
CAS PubMed Google Scholar
Morris BJ: Seven sirtuins for seven deadly diseases of aging. Free Radic Biol Med. 2012
Google Scholar
Tanno M, Kuno A, Horio Y, Miura T: Emerging beneficial roles of sirtuins in heart failure. Basic Res Cardiol. 2012, 107: 273-
PubMed PubMed Central Google Scholar
Kawashima T, Inuzuka Y, Okuda J, Kato T, Niizuma S, Tamaki Y, Iwanaga Y, Kawamoto A, Narazaki M, Matsuda T, Adachi S, Takemura G, Kita T, Kimura T, Shioi T: Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice. J Mol Cell Cardiol. 2011, 51: 1026-1036.
CAS PubMed Google Scholar
Nadtochiy SM, Yao H, McBurney MW, Gu W, Guarente L, Rahman I, Brookes PS: SIRT1-mediated acute cardioprotection. Am J Physiol Heart Circ Physiol. 2011, 301: H1506-H1512.
CAS PubMed PubMed Central Google Scholar
Nadtochiy SM, Redman E, Rahman I, Brookes PS: Lysine deacetylation in ischaemic preconditioning: the role of SIRT1. Cardiovasc Res. 2011, 89: 643-649.
CAS PubMed Google Scholar
Chong ZZ, Wang S, Shang YC, Maiese K: Targeting cardiovascular disease with novel SIRT1 pathways. Future Cardiol. 2012, 8: 89-100.
CAS PubMed PubMed Central Google Scholar
Narayan N, Lee IH, Borenstein R, Sun J, Wong R, Tong G, Fergusson MM, Liu J, Rovira II, Cheng H-L, Wang G, Gucek M, Lombard D, Alt FW, Sack MN, Murphy E, Cao L, Finkel T: The NAD-dependent deacetylase SIRT2 is required for programmed necrosis. Nature. 2012, 492: 199-204.
CAS PubMed Google Scholar
Choudhary C, Kumar C, Gnad F, Nielsen M, Rehman M, Walther T, Olsen J, Mann M: Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009, 325: 834-840.
CAS PubMed Google Scholar
Sol EM, Wagner SA, Weinert BT, Kumar A, Kim H-S, Deng C-X, Choudhary C: Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3. PLoS ONE. 2012, 7: e50545-
CAS PubMed PubMed Central Google Scholar
Mischerikow N, Heck AJR: Targeted large-scale analysis of protein acetylation. Proteomics. 2011, 11: 571-589.
CAS PubMed Google Scholar
Li T, Evdokimov E, Shen R-F, Chao C-C, Tekle E, Wang T, Stadtman ER, Yang DCH, Chock PB: Sumoylation of heterogeneous nuclear ribonucleoproteins, zinc finger proteins, and nuclear pore complex proteins: a proteomic analysis. Proc Natl Acad Sci USA. 2004, 101: 8551-8556.
CAS PubMed PubMed Central Google Scholar
Matafora V, D'Amato A, Mori S, Blasi F, Bachi A: Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition. Mol Cell Proteomics. 2009, 8: 2243-2255.
CAS PubMed PubMed Central Google Scholar
Flick K, Kaiser P: Proteomic revelation: SUMO changes partners when the heat is on. Science Signaling. 2009, 2: pe45-
PubMed PubMed Central Google Scholar
Wang J, Schwartz RJ: Sumoylation and regulation of cardiac gene expression. Circ Res. 2010, 107: 19-29.
CAS PubMed PubMed Central Google Scholar
Wang J: Cardiac function and disease: emerging role of small ubiquitin-related modifier. Wiley Interdiscip Rev Syst Biol Med. 2011, 3: 446-457.
CAS PubMed Google Scholar
Benson MD, Li Q-J, Kieckhafer K, Dudek D, Whorton MR, Sunahara RK, Iñiguez-Lluhí JA, Martens JR: SUMO modification regulates inactivation of the voltage-gated potassium channel Kv1.5. Proc Natl Acad Sci USA. 2007, 104: 1805-1810.
CAS PubMed PubMed Central Google Scholar
Liu H, Zein El L, Kruse M, Guinamard R, Beckmann A, Bozio A, Kurtbay G, Mégarbané A, Ohmert I, Blaysat G, Villain E, Pongs O, Bouvagnet P: Gain-of-function mutations in TRPM4 cause autosomal dominant isolated cardiac conduction disease. Circ Cardiovasc Genet. 2010, 3: 374-385.
CAS PubMed Google Scholar
Kim EY, Chen L, Ma Y, Yu W, Chang J, Moskowitz IP, Wang J: Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction. J Mol Cell Cardiol. 2012, 52: 638-649.
CAS PubMed Google Scholar
Kim EY, Chen L, Ma Y, Yu W, Chang J, Moskowitz IP, Wang J: Expression of sumoylation deficient Nkx2.5 mutant in Nkx2.5 haploinsufficient mice leads to congenital heart defects. PLoS ONE. 2011, 6: e20803-
CAS PubMed PubMed Central Google Scholar
Schwartz RJ, Yeh ETH: Weighing in on heart failure: the role of SERCA2a SUMOylation. Circ Res. 2012, 110: 198-199.
CAS PubMed Google Scholar
Kho C, Lee A, Jeong D, Oh JG, Chaanine AH, Kizana E, Park WJ, Hajjar RJ: SUMO1-dependent modulation of SERCA2a in heart failure. Nature. 2011, 477: 601-605.
CAS PubMed PubMed Central Google Scholar
Blomster HA, Imanishi SY, Siimes J, Kastu J, Morrice NA, Eriksson JE, Sistonen L: In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification. J Biol Chem. 2010, 285: 19324-19329.
CAS PubMed PubMed Central Google Scholar
Tatham MH, Rodriguez MS, Xirodimas DP, Hay RT: Detection of protein SUMOylation in vivo. Nat Protoc. 2009, 4: 1363-1371.
CAS PubMed Google Scholar
Galisson F, Mahrouche L, Courcelles M, Bonneil E, Meloche S, Chelbi-Alix MK, Thibault P: A novel proteomics approach to identify SUMOylated proteins and their modification sites in human cells. Mol Cell Proteomics. 2011, 10: M110.004796-
PubMed Google Scholar
Bicker KL, Thompson PR: The protein arginine deiminases: Structure, function, inhibition, and disease. Biopolymers. 2013, 99: 155-163.
CAS PubMed PubMed Central Google Scholar
Serra-Bonett N, Rodriguez MA: The swollen joint, the thickened artery, and the smoking gun: tobacco exposure, citrullination and rheumatoid arthritis. Rheumatol Int. 2011, 31: 567-572.
CAS PubMed Google Scholar
Giles JT, Fert-Bober J, Park JK, Bingham CO3, Andrade F, Fox-Talbot K, Pappas D, Rosen A, Van Eyk J, Bathon JM, Halushka MK: Myocardial citrullination in rheumatoid arthritis: a correlative histopathologic study. Arthritis Res Ther. 2012, 14: R39-
PubMed PubMed Central Google Scholar
De Ceuleneer M, Van Steendam K, Dhaenens M, Deforce D: In vivo relevance of citrullinated proteins and the challenges in their detection. Proteomics. 2012, 12: 752-760.
CAS PubMed Google Scholar
Zhang Q, Ames JM, Smith RD, Baynes JW, Metz TO: A perspective on the Maillard reaction and the analysis of protein glycation by mass spectrometry: probing the pathogenesis of chronic disease. J Proteome Res. 2009, 8: 754-769.
CAS PubMed PubMed Central Google Scholar
Singh DK, Winocour P, Farrington K: Oxidative stress in early diabetic nephropathy: fueling the fire. Nat Rev Endocrinol. 2011, 7: 176-184.
CAS PubMed Google Scholar
Goova MT, Li J, Kislinger T, Qu W, Lu Y, Bucciarelli LG, Nowygrod S, Wolf BM, Caliste X, Yan S-F, Stern DM, Schmidt AM: Blockade of receptor for advanced glycation end-products restores effective wound healing in diabetic mice. Am J Pathol. 2001, 159: 513-525.
CAS PubMed PubMed Central Google Scholar
Basta G, Schmidt AM, De Caterina R: Advanced glycation end products and vascular inflammation: implications for accelerated atherosclerosis in diabetes. Cardiovasc Res. 2004, 63: 582-592.
CAS PubMed Google Scholar
Yeh CH, Sturgis L, Haidacher J, Zhang XN, Sherwood SJ, Bjercke RJ, Juhasz O, Crow MT, Tilton RG, Denner L: Requirement for p38 and p44/p42 mitogen-activated protein kinases in RAGE-mediated nuclear factor-kappaB transcriptional activation and cytokine secretion. Diabetes. 2001, 50: 1495-1504.
CAS PubMed Google Scholar
Susic D: Cross-link breakers as a new therapeutic approach to cardiovascular disease. Biochem Soc Trans. 2007, 35: 853-856.
CAS PubMed Google Scholar
Diguet N, Mallat Y, Ladouce R, Clodic G, Prola A, Tritsch E, Blanc J, Larcher J-C, Delcayre C, Samuel J-L, Friguet B, Bolbach G, Li Z, Mericskay M: Muscle creatine kinase deficiency triggers both actin depolymerization and desmin disorganization by advanced glycation end products in dilated cardiomyopathy. J Biol Chem. 2011, 286: 35007-35019.
CAS PubMed PubMed Central Google Scholar
Colhoun HM, Betteridge DJ, Durrington P, Hitman G, Neil A, Livingstone S, Charlton-Menys V, Bao W, Demicco DA, Preston GM, Deshmukh H, Tan K, Fuller JH: Total soluble and endogenous secretory receptor for advanced glycation end products as predictive biomarkers of coronary heart disease risk in patients with type 2 diabetes: an analysis from the CARDS trial. Diabetes. 2011, 60: 2379-2385.
CAS PubMed PubMed Central Google Scholar
Simm A, Wagner J, Gursinsky T, Nass N, Friedrich I, Schinzel R, Czeslik E, Silber RE, Scheubel RJ: Advanced glycation endproducts: a biomarker for age as an outcome predictor after cardiac surgery?. Exp Gerontol. 2007, 42: 668-675.
CAS PubMed Google Scholar
Hartog JWL, Voors AA, Schalkwijk CG, Scheijen J, Smilde TDJ, Damman K, Bakker SJL, Smit AJ, van Veldhuisen DJ: Clinical and prognostic value of advanced glycation end-products in chronic heart failure. Eur Heart J. 2007, 28: 2879-2885.
CAS PubMed Google Scholar
Koyama Y, Takeishi Y, Arimoto T, Niizeki T, Shishido T, Takahashi H, Nozaki N, Hirono O, Tsunoda Y, Nitobe J, Watanabe T, Kubota I: High serum level of pentosidine, an advanced glycation end product (AGE), is a risk factor of patients with heart failure. J Card Fail. 2007, 13: 199-206.
CAS PubMed Google Scholar
Kilhovd BK, Juutilainen A, Lehto S, Rönnemaa T, Torjesen PA, Hanssen KF, Laakso M: Increased serum levels of advanced glycation endproducts predict total, cardiovascular and coronary mortality in women with type 2 diabetes: a population-based 18 year follow-up study. Diabetologia. 2007, 50: 1409-1417.
CAS PubMed Google Scholar
Zhang Q, Monroe ME, Schepmoes AA, Clauss TRW, Gritsenko MA, Meng D, Petyuk VA, Smith RD, Metz TO: Comprehensive identification of glycated peptides and their glycation motifs in plasma and erythrocytes of control and diabetic subjects. J Proteome Res. 2011, 10: 3076-3088.
CAS PubMed PubMed Central Google Scholar
Robinson NE, Robinson AB: Deamidation of human proteins. Proc Natl Acad Sci USA. 2001, 98: 12409-12413.
CAS PubMed PubMed Central Google Scholar
Hains PG, Truscott RJW: Age-dependent deamidation of lifelong proteins in the human lens. Invest Ophthalmol Vis Sci. 2010, 51: 3107-3114.
PubMed PubMed Central Google Scholar
Ren J, Zhang S, Kovacs A, Wang Y, Muslin AJ: Role of p38alpha MAPK in cardiac apoptosis and remodeling after myocardial infarction. J Mol Cell Cardiol. 2005, 38: 617-623.
CAS PubMed Google Scholar
White MY, Cordwell SJ, McCarron HCK, Tchen AS, Hambly BD, Jeremy RW: Modifications of myosin-regulatory light chain correlate with function of stunned myocardium. J Mol Cell Cardiol. 2003, 35: 833-840.
CAS PubMed Google Scholar
Overall CM, Blobel CP: In search of partners: linking extracellular proteases to substrates. Nat Rev Mol Cell Biol. 2007, 8: 245-257.
CAS PubMed Google Scholar
Puente XS, Sánchez LM, Overall CM, López-Otín C: Human and mouse proteases: a comparative genomic approach. Nat Rev Genet. 2003, 4: 544-558.
CAS PubMed Google Scholar
Klingler D, Hardt M: Targeting proteases in cardiovascular diseases by mass spectrometry-based proteomics. Circ Cardiovasc Genet. 2012, 5: 265-
PubMed PubMed Central Google Scholar
Müller AL, Dhalla NS: Role of various proteases in cardiac remodeling and progression of heart failure. Heart Fail Rev. 2012, 17: 395-409.
PubMed Google Scholar
Kleifeld O, Doucet A, auf dem Keller U, Prudova A, Schilling O, Kainthan RK, Starr AE, Foster LJ, Kizhakkedathu JN, Overall CM: Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products. Nat Biotech. 2010, 28: 281-288. 10.1038/nbt.1611.
CAS Google Scholar
Kleifeld O, Doucet A, Prudova A, auf dem Keller U, Gioia M, Kizhakkedathu JN, Overall CM: Identifying and quantifying proteolytic events and the natural N terminome by terminal amine isotopic labeling of substrates. Nat Protoc. 2011, 6: 1578-1611.
CAS PubMed Google Scholar
Schilling O, Barré O, Huesgen PF, Overall CM: Proteome-wide analysis of protein carboxy termini: C terminomics. Nat Methods. 2010, 7: 508-511.
CAS PubMed Google Scholar
Doucet A, Overall CM: Amino-Terminal Oriented Mass Spectrometry of Substrates (ATOMS) N-terminal sequencing of proteins and proteolytic cleavage sites by quantitative mass spectrometry. Methods Enzymol. 2011, 501: 275-293.
CAS PubMed Google Scholar
Becker-Pauly C, Barré O, Schilling O, auf dem Keller U, Ohler A, Broder C, Schütte A, Kappelhoff R, Stöcker W, Overall CM: Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates. Mol Cell Proteomics. 2011, 10: M111.009233-
PubMed PubMed Central Google Scholar
Prudova A, auf dem Keller U, Butler GS, Overall CM: Multiplex N-terminome analysis of MMP-2 and MMP-9 substrate degradomes by iTRAQ-TAILS quantitative proteomics. Mol Cell Proteomics. 2010, 9: 894-911.
CAS PubMed PubMed Central Google Scholar
Starr AE, Bellac CL, Dufour A, Goebeler V, Overall CM: Biochemical characterization and N-terminomics analysis of leukolysin, the membrane-type 6 matrix metalloprotease (MMP25): chemokine and vimentin cleavages enhance cell migration and macrophage phagocytic activities. J Biol Chem. 2012, 287: 13382-13395.
CAS PubMed PubMed Central Google Scholar
Bolli R, Patel BS, Jeroudi MO, Lai EK, McCay PB: Demonstration of free radical generation in "stunned" myocardium of intact dogs with the use of the spin trap alpha-phenyl N-tert-butyl nitrone. J Clin Invest. 1988, 82: 476-485.
CAS PubMed PubMed Central Google Scholar
Jacob C, Giles GI, Giles NM, Sies H: Sulfur and selenium: the role of oxidation state in protein structure and function. Angew Chem Int Ed Engl. 2003, 42: 4742-4758.
CAS PubMed Google Scholar
Lassègue B, San Martín A, Griendling KK: Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system. Circ Res. 2012, 110: 1364-1390.
PubMed PubMed Central Google Scholar
Santos CXC, Anilkumar N, Zhang M, Brewer AC, Shah AM: Redox signaling in cardiac myocytes. Free Radic Biol Med. 2011, 50: 777-793.
CAS PubMed PubMed Central Google Scholar
Burgoyne JR, Mongue-Din H, Eaton P, Shah AM: Redox signaling in cardiac physiology and pathology. Circ Res. 2012, 111: 1091-1106.
CAS PubMed Google Scholar
Zhang Y, Tocchetti CG, Krieg T, Moens AL: Oxidative and nitrosative stress in the maintenance of myocardial function. Free Radic Biol Med. 2012, 53: 1531-1540.
CAS PubMed Google Scholar
Wang X, Jian C, Zhang X, Huang Z, Xu J, Hou T, Shang W, Ding Y, Zhang W, Ouyang M, Wang Y, Yang Z, Zheng M, Cheng H: Superoxide flashes: elemental events of mitochondrial ROS signaling in the heart. J Mol Cell Cardiol. 2012, 52: 940-948.
CAS PubMed Google Scholar
Tabima DM, Frizzell S, Gladwin MT: Reactive oxygen and nitrogen species in pulmonary hypertension. Free Radic Biol Med. 2012, 52: 1970-1986.
CAS PubMed Google Scholar
Chalkias A, Xanthos T: Redox-mediated programed death of myocardial cells after cardiac arrest and cardiopulmonary resuscitation. Redox Rep. 2012, 17: 80-83.
CAS PubMed Google Scholar
Pacher P, Beckman JS, Liaudet L: Nitric oxide and peroxynitrite in health and disease. Physiol Rev. 2007, 87: 315-424.
CAS PubMed PubMed Central Google Scholar
Ge Y, Moss RL: Nitroxyl, redox switches, cardiac myofilaments, and heart failure: a prequel to novel therapeutics?. Circ Res. 2012, 111: 954-956.
CAS PubMed PubMed Central Google Scholar
Murray CI, Uhrigshardt H, O'Meally RN, Cole RN, van Eyk JE: Identification and quantification of S-nitrosylation by cysteine reactive tandem mass tag switch assay. Mol Cell Proteomics. 2012, 11: M111.013441-
PubMed Google Scholar
Wang H, Qian W-J, Chin MH, Petyuk VA, Barry RC, Liu T, Gritsenko MA, Mottaz HM, Moore RJ, Camp Ii DG, Khan AH, Smith DJ, Smith RD: Characterization of the mouse brain proteome using global proteomic analysis complemented with cysteinyl-peptide enrichment. J Proteome Res. 2006, 5: 361-369.
CAS PubMed PubMed Central Google Scholar
Lee J-S, Smith E, Shilatifard A: The language of histone crosstalk. Cell. 2010, 142: 682-685.
CAS PubMed PubMed Central Google Scholar
Mishra S, Ande SR, Salter NW: O-GlcNAc modification: why so intimately associated with phosphorylation?. Cell Commun Signal. 2011, 9: 1,DOI:10.1186/1478-811X-9-1
CAS PubMed PubMed Central Google Scholar
Gu Y, Ande SR, Mishra S: Altered O-GlcNAc modification and phosphorylation of mitochondrial proteins in myoblast cells exposed to high glucose. Arch Biochem Biophys. 2011, 505: 98-104.
CAS PubMed Google Scholar
Wang Z, Gucek M, Hart GW: Cross-talk between GlcNAcylation and phosphorylation: site-specific phosphorylation dynamics in response to globally elevated O-GlcNAc. Proc Natl Acad Sci USA. 2008, 105: 13793-13798.
CAS PubMed PubMed Central Google Scholar
Graham ME, Thaysen-Andersen M, Bache N, Craft GE, Larsen MR, Packer NH, Robinson PJ: A novel post-translational modification in nerve terminals: O-linked N-acetylglucosamine phosphorylation. J Proteome Res. 2011, 10: 2725-2733.
CAS PubMed Google Scholar
Hahne H, Kuster B: Discovery of O-GlcNAc-6-phosphate modified proteins in large-scale phosphoproteomics data. Mol Cell Proteomics. 2012, 11: 1063-1069.
CAS PubMed PubMed Central Google Scholar
Matic I, Schimmel J, Hendriks IA, van Santen MA, van de Rijke F, van Dam H, Gnad F, Mann M, Vertegaal ACO: Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif. Mol Cell. 2010, 39: 641-652.
CAS PubMed Google Scholar
Yao Q, Li H, Liu B-Q, Huang X-Y, Guo L: SUMOylation-regulated protein phosphorylation, evidence from quantitative phosphoproteomics analyses. J Biol Chem. 2011, 286: 27342-27349.
CAS PubMed PubMed Central Google Scholar
Ruderman NB, Xu XJ, Nelson L, Cacicedo JM, Saha AK, Lan F, Ido Y: AMPK and SIRT1: a long-standing partnership?. Am J Physiol Endocrinol Metab. 2010, 298: E751-E760.
CAS PubMed PubMed Central Google Scholar
Low JKK, Wilkins MR: Protein arginine methylation in Saccharomyces cerevisiae. FEBS J. 2012, 279: 4423-4443.
CAS PubMed Google Scholar
Chen C, Nott TJ, Jin J, Pawson T: Deciphering arginine methylation: Tudor tells the tale. Nat Rev Mol Cell Biol. 2011, 12: 629-642.
CAS PubMed Google Scholar
Black JC, Whetstine JR: Tipping the lysine methylation balance in disease. Biopolymers. 2013, 99: 127-135.
CAS PubMed Google Scholar
Calise J, Powell SR: The ubiquitin proteasome system and myocardial ischemia. Am J Physiol Heart Circ Physiol. 2012, 304: H337-H349.
PubMed PubMed Central Google Scholar
Download references