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Which symptoms should be assessed for in a patient suspected of having GERD?
Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

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    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Furuya-Kanamori L, Stone JC, Clark J, et al. Comorbidities, exposure to medications, and the risk of community-acquiredClostridium difficileinfection: a systematic review and meta-analysis. Infect Control Hosp Epidemiol 2015;36:132-141.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Arriola V, Tischendorf J, Musuuza J, Barker A, Rozelle JW, Safdar N. Assessing the risk of hospital-acquiredClostridium difficileinfection with proton pump inhibitor use: a meta-analysis. Infect Control Hosp Epidemiol 2016;37:1408-1417.

  • Tariq R, Singh S, Gupta A, Pardi DS, Khanna S. Association of gastric acid suppression with recurrentClostridium difficileinfection: a systematic review and meta-analysis. JAMA Intern Med 2017;177:784-791.

  • Trifan A, Stanciu C, Girleanu I, et al. Proton pump inhibitors therapy and risk ofClostridium difficileinfection: systematic review and meta-analysis. World J Gastroenterol 2017;23:6500-6515.

  • Cao F, Chen CX, Wang M, et al. Updated meta-analysis of controlled observational studies: proton-pump inhibitors and risk ofClostridium difficileinfection. J Hosp Infect 2018;98:4-13.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Beil W, Hackbarth I, Sewing KF. Mechanism of gastric antisecretory effect of SCH 28080. Br J Pharmacol 1986;88:19-23.

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  • Ashida K, Sakurai Y, Hori T, et al. Randomized clinical trial: vonoprazan, a novel potassium-competitive acid blocker, vs. lansoprazole for the healing of erosive oesophagitis. Aliment Pharmacol Ther 2016;43:240-251.

  • Ashida K, Sakurai Y, Nishimura A, et al. Randomized clinical trial: adose-ranging study of vonoprazan, a novel potassium-competitive acid blocker, vs. lansoprazole for the treatment of erosive oesophagitis. Aliment Pharmacol Ther 2015;42:685-695.

  • Miyazaki H, Igarashi A, Takeuchi T, et al. Vonoprazan versus proton-pump inhibitors for healing gastroesophageal reflux disease: a systematic review. J Gastroenterol Hepatol 2019;34:1316-1328.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Lee KJ, Son BK, Kim GH, et al. Randomized phase 3 trial: tegoprazan, a novel potassium-competitive acid blocker, vs. esomeprazole in patients with erosive oesophagitis. Aliment Pharmacol Ther 2019;49:864-872.

  • Kim DK, Lee KH, Kim SJ, et al. Effects of tegoprazan, a novel potassium-competitive acid blocker, on rat models of gastric acid-related disease. J Pharmacol Exp Ther 2019;369:318-327.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Han S, Choi HY, Kim YH, et al. Randomized clinical trial: safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple oral doses of tegoprazan (CJ-12420), a novel potassium-competitive acid blocker, in healthy male subjects. Aliment Pharmacol Ther 2019;50:751-759.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Takahashi N, Take Y. Tegoprazan, a novel potassium-competitive acid blocker to control gastric acid secretion and motility. J Pharmacol Exp Ther 2018;364:275-286.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Peghini PL, Katz PO, Bracy NA, Castell DO. Nocturnal recovery of gastric acid secretion with twice-daily dosing of proton pump inhibitors. Am J Gastroenterol 1998;93:763-767.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Savarino V, Di Mario F, Scarpignato C. Proton pump inhibitors in GORD an overview of their pharmacology, efficacy and safety. Pharmacol Res 2009;59:135-153.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Rackoff A, Agrawal A, Hila A, Mainie I, Tutuian R, Castell DO. Histamine-2 receptor antagonists at night improve gastroesophageal reflux disease symptoms for patients on proton pump inhibitor therapy. Dis Esophagus 2005;18:370-373.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Mainie I, Tutuian R, Castell DO. Addition of a H2 receptor antagonist to PPI improves acid control and decreases nocturnal acid breakthrough. J Clin Gastroenterol 2008;42:676-679.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Peghini PL, Katz PO, Castell DO. Ranitidine controls nocturnal gastric acid breakthrough on omeprazole: a controlled study in normal subjects. Gastroenterology 1998;115:1335-1339.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Khoury RM, Katz PO, Hammod R, Castell DO. Bedtime ranitidine does not eliminate the need for a second daily dose of omeprazole to suppress nocturnal gastric pH. Aliment Pharmacol Ther 1999;13:675-678.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Janiak P, Thumshirn M, Menne D, et al. Clinical trial: the effects of adding ranitidine at night to twice daily omeprazole therapy on nocturnal acid breakthrough and acid reflux in patients with systemic sclerosis--a randomized controlled, cross-over trial. Aliment Pharmacol Ther 2007;26:1259-1265.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Wang Y, Pan T, Wang Q, Guo Z. Additional bedtime H2-receptor antagonist for the control of nocturnal gastric acid breakthrough:Cd004275.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Fackler WK, Ours TM, Vaezi MF, Richter JE. Long-term effect of H2RA therapy on nocturnal gastric acid breakthrough. Gastroenterology 2002;122:625-632.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Fass R, Shapiro M, Dekel R, Sewell J. Systematic review: proton-pump inhibitor failure in gastro-oesophageal reflux disease--where next? Aliment Pharmacol Ther 2005;22:79-94.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Miwa H, Inoue K, Ashida K, et al. Randomized clinical trial: efficacy of the addition of a prokinetic, mosapride citrate, to omeprazole in the treatment of patients with non-erosive reflux disease - a double-blind, placebo-controlled study. Aliment Pharmacol Ther 2011;33:323-332.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Miyamoto M, Manabe N, Haruma K. Efficacy of the addition of prokinetics for proton pump inhibitor (PPI) resistant non-erosive reflux disease (NERD) patients: significance of frequency scale for the symptom of GERD (FSSG) on decision of treatment strategy. Intern Med 2010;49:1469-1476.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Liu Q, Feng CC, Wang EM, Yan XJ, Chen SL. Efficacy of mosapride plus proton pump inhibitors for treatment of gastroesophageal reflux disease: a systematic review. World J Gastroenterol 2013;19:9111-9118.

  • Grossi L, Spezzaferro M, Sacco LF, Marzio L. Effect of baclofen on oesophageal motility and transient lower oesophageal sphincter relaxations in GORD patients: a 48-h manometric study. Neurogastroenterol Motil 2008;20:760-766.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Koek GH, Sifrim D, Lerut T, Janssens J, Tack J. Effect of the GABA(B) agonist baclofen in patients with symptoms and duodeno-gastro-oesophageal reflux refractory to proton pump inhibitors. Gut 2003;52:1397-1402.

  • van Herwaarden MA, Samsom M, Rydholm H, Smout AJ. The effect of baclofen on gastro-oesophageal reflux, lower oesophageal sphincter function and reflux symptoms in patients with reflux disease. Aliment Pharmacol Ther 2002;16:1655-1662.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Ciccaglione AF, Marzio L. Effect of acute and chronic administration of the GABA B agonist baclofen on 24 hour pH metry and symptoms in control subjects and in patients with gastro-oesophageal reflux disease. Gut 2003;52:464-470.

  • Cossentino MJ, Mann K, Armbruster SP, Lake JM, Maydonovitch C, Wong RK. Randomized clinical trial: the effect of baclofen in patients with gastro-oesophageal reflux--a randomized prospective study. Aliment Pharmacol Ther 2012;35:1036-1044.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Cange L, Johnsson E, Rydholm H, et al. Baclofen-mediated gastro-oesophageal acid reflux control in patients with established reflux disease. Aliment Pharmacol Ther 2002;16:869-873.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Li S, Shi S, Chen F, Lin J. The effects of baclofen for the treatment of gastroesophageal reflux disease: a meta-analysis of randomized controlled trials. Gastroenterol Res Pract 2014;2014:307805.

  • Sandhu DS, Fass R. Current trends in the management of gastroesophageal reflux disease. Gut Liver 2018;12:7-16.

  • Mandel KG, Daggy BP, Brodie DA, Jacoby HI. Review article: alginate-raft formulations in the treatment of heartburn and acid reflux. Aliment Pharmacol Ther 2000;14:669-690.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Kahrilas PJ, McColl K, Fox M, et al. The acid pocket: a target for treatment in reflux disease? Am J Gastroenterol 2013;108:1058-1064.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Kwiatek MA, Roman S, Fareeduddin A, Pandolfino JE, Kahrilas PJ. An alginate-antacid formulation (gaviscon double action liquid) can eliminate or displace the postprandial 'acid pocket' in symptomatic GERD patients. Aliment Pharmacol Ther 2011;34:59-66.

  • Thomas E, Wade A, Crawford G, Jenner B, Levinson N, Wilkinson J. Randomized clinical trial: relief of upper gastrointestinal symptoms by an acid pocket-targeting alginate-antacid (gaviscon double action) - a double-blind, placebo-controlled, pilot study in gastro-oesophageal reflux disease. Aliment Pharmacol Ther 2014;39:595-602.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Savarino E, de Bortoli N, Zentilin P, et al. Alginate controls heartburn in patients with erosive and nonerosive reflux disease. World J Gastroenterol 2012;18:4371-4378.

  • Yuan YZ, Fang JY, Zou DW, Levinson N, Jenner B, Wilkinson J. Alginate antacid (Gaviscon DA) chewable tablets reduce esophageal acid exposure in Chinese patients with gastroesophageal reflux disease and heartburn symptoms. J Dig Dis 2016;17:725-734.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • De Ruigh A, Roman S, Chen J, Pandolfino JE, Kahrilas PJ. Gaviscon double action liquid (antacid & alginate) is more effective than antacid in controlling post-prandial oesophageal acid exposure in GERD patients: a double-blind crossover study. Aliment Pharmacol Ther 2014;40:531-537.

  • Wilkinson J, Wade A, Thomas SJ, Jenner B, Hodgkinson V, Coyle C. Randomized clinical trial: a double-blind, placebo-controlled study to assess the clinical efficacy and safety of alginate-antacid (gaviscon double action) chewable tablets in patients with gastro-oesophageal reflux disease. Eur J Gastroenterol Hepatol 2019;31:86-93.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Lai IR, Wu MS, Lin JT. Prospective, randomized, and active controlled study of the efficacy of alginic acid and antacid in the treatment of patients with endoscopy-negative reflux disease. World J Gastroenterol 2006;12:747-754.

  • Tran T, Lowry AM, El-Serag HB. Meta-analysis: the efficacy of over-the-counter gastro-oesophageal reflux disease therapies. Aliment Pharmacol Ther 2007;25:143-153.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Chiu CT, Hsu CM, Wang CC, et al. Randomized clinical trial: sodium alginate oral suspension is non-inferior to omeprazole in the treatment of patients with non-erosive gastroesophageal disease. Aliment Pharmacol Ther 2013;38:1054-1064.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Coyle C, Crawford G, Wilkinson J, Thomas SJ, Bytzer P. Randomized clinical trial: addition of alginate-antacid (gaviscon double action) to proton pump inhibitor therapy in patients with breakthrough symptoms. Aliment Pharmacol Ther 2017;45:1524-1533.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Kim JH, Lee YC, Kim EH, et al. The clinical efficacy of a pure alginate formulation (lamina g) for controlling symptoms in individuals with reflux symptoms: a randomized clinical study. Gut Liver 2019;13:642-648.

  • Reimer C, Lødrup AB, Smith G, Wilkinson J, Bytzer P. Randomized clinical trial: alginate (gaviscon advance) vs. placebo as add-on therapy in reflux patients with inadequate response to a once daily proton pump inhibitor. Aliment Pharmacol Ther 2016;43:899-909.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Leiman DA, Riff BP, Morgan S, et al. Alginate therapy is effective treatment for GERD symptoms: a systematic review and meta-analysis. Dis Esophagus 2017;30:1-9.

  • Fass R, Cahn F, Scotti DJ, Gregory DA. Systematic review and meta-analysis of controlled and prospective cohort efficacy studies of endoscopic radiofrequency for treatment of gastroesophageal reflux disease. Surg Endosc 2017;31:4865-4882.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Lipka S, Kumar A, Richter JE. No evidence for efficacy of radiofrequency ablation for treatment of gastroesophageal reflux disease: a systematic review and meta-analysis. Clin Gastroenterol Hepatol 2015;13:1058-1067, e1.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Perry KA, Banerjee A, Melvin WS. Radiofrequency energy delivery to the lower esophageal sphincter reduces esophageal acid exposure and improves GERD symptoms: a systematic review and meta-analysis. Surg Laparosc Endosc Percutan Tech 2012;22:283-288.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Noar M, Squires P, Noar E, Lee M. Long-term maintenance effect of radiofrequency energy delivery for refractory GERD: a decade later. Surg Endosc 2014;28:2323-2333.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Lundell L, Miettinen P, Myrvold HE, et al. Continued (5-year) followup of a randomized clinical study comparing antireflux surgery and omeprazole in gastroesophageal reflux disease. J Am Coll Surg 2001;192:172-179; discussion 179-181.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Lundell L, Miettinen P, Myrvold HE, et al. Seven-year follow-up of a randomized clinical trial comparing proton-pump inhibition with surgical therapy for reflux oesophagitis. Br J Surg 2007;94:198-203.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Myrvold HE, Lundell L, Miettinen P, et al. The cost of long-term therapy for gastro-oesophageal reflux disease: a randomized trial comparing omeprazole and open antireflux surgery. Gut 2001;49:488-494.

  • Mehta S, Bennett J, Mahon D, Rhodes M. Prospective trial of laparoscopic nissen fundoplication versus proton pump inhibitor therapy for gastroesophageal reflux disease: seven-year follow-up. J Gastrointest Surg 2006;10:1312-1316; discussion 1316-1317.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Anvari M, Allen C, Marshall J, et al. A randomized controlled trial of laparoscopic nissen fundoplication versus proton pump inhibitors for the treatment of patients with chronic gastroesophageal reflux disease (GERD): 3-year outcomes. Surg Endosc 2011;25:2547-2554.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Cookson R, Flood C, Koo B, Mahon D, Rhodes M. Short-term cost effectiveness and long-term cost analysis comparing laparoscopic nissen fundoplication with proton-pump inhibitor maintenance for gastro-oesophageal reflux disease. Br J Surg 2005;92:700-706.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Epstein D, Bojke L, Sculpher MJ. Laparoscopic fundoplication compared with medical management for gastro-oesophageal reflux disease: cost effectiveness study. BMJ 2009;339:b2576.

  • Grant AM, Boachie C, Cotton SC, et al. Clinical and economic evaluation of laparoscopic surgery compared with medical management for gastro-oesophageal reflux disease: 5-year follow-up of multicentre randomized trial (the REFLUX trial). Health Technol Assess 2013;17:1-167.

  • Hatlebakk JG, Zerbib F, et al; Bruley des Varannes S. Gastroesophageal acid reflux control 5 years after antireflux surgery, compared with long-term esomeprazole therapy. Clin Gastroenterol Hepatol 2016;14:678-685, e3.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Emken BG, Lundell LR, Wallin L, et al. Effects of omeprazole or anti-reflux surgery on lower oesophageal sphincter characteristics and oesophageal acid exposure over 10 years. Scand J Gastroenterol 2017;52:11-17.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Park S, Park S, Park JM, et al. Anti-reflux surgery versus proton pump inhibitors for severe gastroesophageal reflux disease: a cost-effectiveness study in Korea. J Neurogastroenterol Motil 2020;26:215-223.

  • Mahon D, Rhodes M, Decadt B, et al. Randomized clinical trial of laparoscopic nissen fundoplication compared with proton-pump inhibitors for treatment of chronic gastro-oesophageal reflux. Br J Surg 2005;92:695-699.

    Which symptoms should be assessed for in a patient suspected of having GERD?
    Which symptoms should be assessed for in a patient suspected of having GERD?

  • Grant AM, Wileman SM, Ramsay CR, et al. Minimal access surgery compared with medical management for chronic gastro-oesophageal reflux disease: UK collaborative randomised trial. BMJ 2008;337:a2664.

    What should you assess for GERD?

    The diagnosis of GERD is typically made by a combination of clinical symptoms, response to acid suppression, as well as objective testing with upper endoscopy and esophageal pH monitoring.

    Which of the following symptoms are typical GERD symptoms?

    Common signs and symptoms of GERD include:.
    A burning sensation in your chest (heartburn), usually after eating, which might be worse at night or while lying down..
    Backwash (regurgitation) of food or sour liquid..
    Upper abdominal or chest pain..
    Trouble swallowing (dysphagia).
    Sensation of a lump in your throat..

    Which of these symptoms would the nurse expect to find in a client with GERD?

    The symptoms of GERD are classified as typical symptoms that include heartburn, sensation of regurgitation and atypical symptoms which are associated with chronic cough, asthma, hoarseness caused by laryngitis, dyspepsia and nausea[9].

    What is the physical assessment of GERD?

    High digestive endoscopy This is the exam of choice in the evaluation of patients with GERD symptoms and it is indicated in chronic cases in patients over 40 years old and with alarm symptoms, such as dysphagia, odynophagia, weight loss, digestive hemorrhage, nausea, vomits, and family history of cancer.