Han, L. K. M. et al. Epigenetic aging in major depressive disorder. Am. J. Psychiatry 175, 774–782 (2018). Show
PubMed PubMed Central Article Google Scholar Penninx, B. W. Depression and cardiovascular disease: epidemiological evidence on their linking mechanisms. Neurosci. Biobehav. Rev. 74(Pt B), 277–286 (2017). PubMed Article Google Scholar Buigues, C. et al. The relationship between depression and frailty syndrome: a systematic review. Aging Ment. Health 19, 762–772 (2015). PubMed Article Google Scholar Daskalopoulou, M. et al. Depression as a risk factor for the initial presentation of twelve cardiac, cerebrovascular, and peripheral arterial diseases: data linkage study of 1.9 million women and men. PLoS ONE 11, e0153838 (2016). PubMed PubMed Central Article CAS Google Scholar Pan, A., Sun, Q., Okereke, O. I., Rexrode, K. M. & Hu, F. B. Depression and risk of stroke morbidity and mortality: a meta-analysis and systematic review. JAMA 306, 1241–1249 (2011). CAS PubMed PubMed Central Article Google Scholar Alexopoulos, G. S. Depression in the elderly. Lancet 365, 1961–1970 (2005). PubMed Article Google Scholar Taylor, W. D., Aizenstein, H. J. & Alexopoulos, G. S. The vascular depression hypothesis: mechanisms linking vascular disease with depression. Mol. Psychiatry 18, 963–974 (2013). CAS PubMed PubMed Central Article Google Scholar Alexopoulos, G. S. et al. Functional connectivity in the cognitive control network and the default mode network in late-life depression. J. Affect. Disord. 139, 56–65 (2012). PubMed PubMed Central Article Google Scholar Yuen, G. S. et al. The salience network in the apathy of late-life depression. Int. J. Geriatr. Psychiatry 29, 1116–1124 (2014). PubMed PubMed Central Article Google Scholar Mulders, P. C., van Eijndhoven, P. F., Schene, A. H., Beckmann, C. F. & Tendolkar, I. Resting-state functional connectivity in major depressive disorder: a review. Neurosci. Biobehav. Rev. 56, 330–344 (2015). PubMed Article Google Scholar Manning, K. J. & Steffens, D. C. State of the science of neural systems in late-life depression: impact on clinical presentation and treatment outcome. J. Am. Geriatr. Soc. 66(Suppl 1), S17–s23 (2018). PubMed PubMed Central Article Google Scholar Alexopoulos, G. S. et al. Microstructural white matter abnormalities and remission of geriatric depression. Am. J. Psychiatry 165, 238–244 (2008). PubMed Article Google Scholar Alexopoulos, G. S. et al. ‘Vascular depression’ hypothesis. Arch. Gen. Psychiatry 54, 915–922 (1997). CAS PubMed Article Google Scholar Januar, V., Ancelin, M. L., Ritchie, K., Saffery, R. & Ryan, J. BDNF promoter methylation and genetic variation in late-life depression. Transl. Psychiatry 5, e619 (2015). CAS PubMed PubMed Central Article Google Scholar Miller, A. H., Haroon, E., Raison, C. L. & Felger, J. C. Cytokine targets in the brain: impact on neurotransmitters and neurocircuits. Depress. Anxiety 30, 297–306 (2013). CAS PubMed PubMed Central Article Google Scholar Hall, B. S., Moda, R. N. & Liston, C. Glucocorticoid mechanisms of functional connectivity changes in stress-related neuropsychiatric disorders. Neurobiol. Stress 1, 174–183 (2015). PubMed Article Google Scholar McEwen, B. Mood disorders and allostatic load. Biol. Psychiatry 54, 200–207 (2003). PubMed Article Google Scholar Diniz, B. S. et al. Plasma biosignature and brain pathology related to persistent cognitive impairment in late-life depression. Mol. Psychiatry 20, 594–601 (2015). CAS PubMed Article Google Scholar Diniz, B. S. et al. Enhanced molecular aging in late-life depression: the senescent-associated secretory phenotype. Am. J. Geriatr. Psychiatry 25, 64–72 (2017). PubMed Article Google Scholar Alexopoulos, G. S. “The depression-executive dysfunction syndrome of late life”: a specific target for D3 agonists? Am. J. Geriatr. Psychiatry 9, 22–29 (2001). CAS PubMed Google Scholar Lim, J. et al. Sensitivity of cognitive tests in four cognitive domains in discriminating MDD patients from healthy controls: a meta-analysis. Int. Psychogeriatr. 25, 1543–1557 (2013). PubMed Article Google Scholar Alexopoulos, G. S., Kiosses, D. N., Klimstra, S., Kalayam, B. & Bruce, M. L. Clinical presentation of the “depression-executive dysfunction syndrome” of late life. Am. J. Geriatr. Psychiatry 10, 98–106 (2002). PubMed Google Scholar Alexopoulos, G. S. et al. Clinically defined vascular depression. Am. J. psychiatry 154, 562–565 (1997). CAS PubMed Article Google Scholar Rapp, M. A. et al. Neuropsychological differences between late-onset and recurrent geriatric major depression. Am. J. Psychiatry 162, 691–698 (2005). PubMed Article Google Scholar Taylor, W. D. et al. Localization of age-associated white matter hyperintensities in late-life depression. Prog. Neuropsychopharmacol. Biol. Psychiatry 27, 539–544 (2003). PubMed Article Google Scholar Alexopoulos, G. S. et al. Serotonin transporter polymorphisms, microstructural white matter abnormalities and remission of geriatric depression. J. Affect. Disord. 119, 132–141 (2009). CAS PubMed PubMed Central Article Google Scholar Bae, J. N. et al. Dorsolateral prefrontal cortex and anterior cingulate cortex white matter alterations in late-life depression. Biol. Psychiatry 60, 1356–1363 (2006). PubMed Article Google Scholar Aizenstein, H. J. et al. Altered functioning of the executive control circuit in late-life depression: episodic and persistent phenomena. Am. J. Geriatr. Psychiatry 17, 30–42 (2009). PubMed PubMed Central Article Google Scholar Yuen, G. S. et al. Apathy in late-life depression: common, persistent, and disabling. Am. J. Geriatr. Psychiatry 23, 488–494 (2015). PubMed Article Google Scholar Hollocks, M. J. et al. Differential relationships between apathy and depression with white matter microstructural changes and functional outcomes. Brain 138(Pt 12), 3803–3815 (2015). PubMed PubMed Central Article Google Scholar Alexopoulos, G. S. et al. Functional connectivity in apathy of late-life depression: a preliminary study. J. Affect. Disord. 149, 398–405 (2013). PubMed Article Google Scholar Kalayam, B. & Alexopoulos, G. S. Prefrontal dysfunction and treatment response in geriatric depression. Arch. Gen. Psychiatry 56, 713–718 (1999). CAS PubMed Article Google Scholar Alexopoulos, G. S. et al. Executive dysfunction and long-term outcomes of geriatric depression. Arch. Gen. Psychiatry 57, 285–290 (2000). CAS PubMed Article Google Scholar Sneed, J. R. et al. Response inhibition predicts poor antidepressant treatment response in very old depressed patients. Am. J. Geriatr. Psychiatry 15, 553–563 (2007). PubMed Article Google Scholar Alexopoulos, G. S., Kiosses, D. N., Murphy, C. & Heo, M. Executive dysfunction, heart disease burden, and remission of geriatric depression. Neuropsychopharmacology 29, 2278–2284 (2004). PubMed Article Google Scholar Potter, G. G., Kittinger, J. D., Wagner, H. R., Steffens, D. C. & Krishnan, K. R. Prefrontal neuropsychological predictors of treatment remission in late-life depression. Neuropsychopharmacology 29, 2266–2271 (2004). PubMed Article Google Scholar Sheline, Y. I. et al. Support for the vascular depression hypothesis in late-life depression: results of a 2-site, prospective, antidepressant treatment trial. Arch. Gen. Psychiatry 67, 277–285 (2010). PubMed PubMed Central Article Google Scholar Manning, K. J. et al. Executive functioning complaints and escitalopram treatment response in late-life depression. Am. J. Geriatr. Psychiatry 23, 440–445 (2015). PubMed Article Google Scholar Gunning-Dixon, F. M. et al. MRI signal hyperintensities and treatment remission of geriatric depression. J. Affect. Disord. 126, 395–401 (2010). PubMed PubMed Central Article Google Scholar Thompson, D. G. et al. FMRI activation during executive function predicts response to cognitive behavioral therapy in older, depressed adults. Am. J. Geriatr. Psychiatry 23, 13–22 (2015). PubMed Article Google Scholar Krishnan, M., Mast, B. T., Ficker, L. J., Lawhorne, L. & Lichtenberg, P. A. The effects of preexisting depression on cerebrovascular health outcomes in geriatric continuing care. J. Gerontol. Ser. A 60, 915–919 (2005). Article Google Scholar Williamson, W. et al. Association of cardiovascular risk factors with mri indices of cerebrovascular structure and function and white matter hyperintensities in young adults. JAMA 320, 665–673 (2018). PubMed PubMed Central Article Google Scholar Arvanitakis, Z. et al. Late-life blood pressure association with cerebrovascular and Alzheimer disease pathology. Neurology 91, e517–e525 (2018). PubMed Article PubMed Central Google Scholar de la Torre, J. C. Cerebral hemodynamics and vascular risk factors: setting the stage for Alzheimer’s disease. J. Alzheimers Dis. 32, 553–567 (2012). PubMed Article Google Scholar Paranthaman, R. et al. Relationship of endothelial function and atherosclerosis to treatment response in late-life depression. Int. J. Geriatr. Psychiatry 27, 967–973 (2012). CAS PubMed Article Google Scholar Rensma, S. P., van Sloten, T. T., Launer, L. J. & Stehouwer, C. D. A. Cerebral small vessel disease and risk of incident stroke, dementia and depression, and all-cause mortality: a systematic review and meta-analysis. Neurosci. Biobehav. Rev. 90, 164–173 (2018). PubMed PubMed Central Article Google Scholar Steffens, D. C., Krishnan, K. R., Crump, C. & Burke, G. L. Cerebrovascular disease and evolution of depressive symptoms in the cardiovascular health study. Stroke 33, 1636–1644 (2002). PubMed Article Google Scholar van Sloten, T. T. et al. Associations between arterial stiffness, depressive symptoms and cerebral small vessel disease: cross-sectional findings from the AGES-Reykjavik Study. J. Psychiatry Neurosci. 41, 162–168 (2016). PubMed Article Google Scholar van Sloten, T. T. et al. Cerebral small vessel disease and association with higher incidence of depressive symptoms in a general elderly population: the AGES-Reykjavik study. Am. J. Psychiatry 172, 570–578 (2015). PubMed PubMed Central Article Google Scholar Prugger, C. et al. Longitudinal association of carotid plaque presence and intima-media thickness with depressive symptoms in the elderly: the three-city study. Arterioscler. Thromb. Vasc. Biol. 35, 1279–1283 (2015). CAS PubMed Article Google Scholar Glassman, A. H., Bigger, J. T., Gaffney, M., Shapiro, P. A. & Swenson, J. R. Onset of major depression associated with acute coronary syndromes: relationship of onset, major depressive disorder history, and episode severity to sertraline benefit. Arch. Gen. Psychiatry 63, 283–288 (2006). PubMed Article Google Scholar Surtees, P. G. et al. Major depression, C-reactive protein, and incident ischemic heart disease in healthy men and women. Psychosom. Med. 70, 850–855 (2008). CAS PubMed Article Google Scholar Miller, A. H., Maletic, V. & Raison, C. L. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol. Psychiatry 65, 732–741 (2009). CAS PubMed PubMed Central Article Google Scholar Zill, P. et al. DNA methylation analysis of the angiotensin converting enzyme (ACE) gene in major depression. PLoS One 7, e40479 (2012). CAS PubMed PubMed Central Article Google Scholar Ancelin, M. L. et al. Angiotensin-converting enzyme gene variants are associated with both cortisol secretion and late-life depression. Transl. Psychiatry 3, e322 (2013). CAS PubMed PubMed Central Article Google Scholar Tenev, V. T., Robinson, R. G. & Jorge, R. E. Is family history of depression a risk factor for poststroke depression? Meta-analysis. Am. J. Geriatr. Psychiatry 17, 276–280 (2009). PubMed PubMed Central Article Google Scholar Krishnan, K. R., Hays, J. C. & Blazer, D. G. MRI-defined vascular depression. Am. J. Psychiatry 154, 497–501 (1997). CAS PubMed Article Google Scholar Reppermund, S. et al. White matter integrity and late-life depression in community-dwelling individuals: diffusion tensor imaging study using tract-based spatial statistics. Br. J. Psychiatry. 205, 315–320 (2014). PubMed Article Google Scholar Taylor, W. D. et al. Fiber tract-specific white matter lesion severity Findings in late-life depression and by AGTR1 A1166C genotype. Hum. Brain Mapp. 34, 295–303 (2013). PubMed Article Google Scholar Sheline, Y. I. et al. Regional white matter hyperintensity burden in automated segmentation distinguishes late-life depressed subjects from comparison subjects matched for vascular risk factors. Am. J. Psychiatry 165, 524–532 (2008). PubMed PubMed Central Article Google Scholar O’Brien, J. T. et al. White matter hyperintensities rather than lacunar infarcts are associated with depressive symptoms in older people: the LADIS study. Am. J. Geriatr. Psychiatry 14, 834–841 (2006). PubMed Article Google Scholar Wen, M. C., Steffens, D. C., Chen, M. K. & Zainal, N. H. Diffusion tensor imaging studies in late-life depression: systematic review and meta-analysis. Int. J. Geriatr. Psychiatry 29, 1173–1184 (2014). PubMed Article Google Scholar Wu, M. et al. Default-mode network connectivity and white matter burden in late-life depression. Psychiatry Res. 194, 39–46 (2011). PubMed PubMed Central Article Google Scholar Aizenstein, H. J. et al. fMRI correlates of white matter hyperintensities in late-life depression. Am. J. Psychiatry 168, 1075–1082 (2011). PubMed PubMed Central Article Google Scholar Santos, M. et al. Neuropathological analysis of lacunes and microvascular lesions in late-onset depression. Neuropathol. Appl. Neurobiol. 36, 661–672 (2010). CAS PubMed PubMed Central Article Google Scholar Tsopelas, C. et al. Neuropathological correlates of late-life depression in older people. Br. J. Psychiatry. 198, 109–114 (2011). PubMed Article Google Scholar Wilson, R. S. et al. Clinical-pathologic study of depressive symptoms and cognitive decline in old age. Neurology 83, 702–709 (2014). PubMed PubMed Central Article Google Scholar Wilson, R. S. et al. Late-life depression is not associated with dementia-related pathology. Neuropsychology 30, 135–142 (2016). PubMed PubMed Central Article Google Scholar Venkatraman, V. K. et al. Executive control function, brain activation and white matter hyperintensities in older adults. Neuroimage 49, 3436–3442 (2010). PubMed Article Google Scholar Mayda, A. B., Westphal, A., Carter, C. S. & DeCarli, C. Late life cognitive control deficits are accentuated by white matter disease burden. Brain 134(Pt 6), 1673–1683 (2011). PubMed PubMed Central Article Google Scholar Sexton, C. E. et al. Magnetic resonance imaging in late-life depression: vascular and glucocorticoid cascade hypotheses. Br. J. Psychiatry 201, 46–51 (2012). PubMed Article Google Scholar Taylor, W. D., MacFall, J. R., Gerig, G. & Krishnan, R. R. Structural integrity of the uncinate fasciculus in geriatric depression: Relationship with age of onset. Neuropsychiatr. Dis. Treat. 3, 669–674 (2007). PubMed PubMed Central Google Scholar Steffens, D. C., Taylor, W. D., Denny, K. L., Bergman, S. R. & Wang, L. Structural integrity of the uncinate fasciculus and resting state functional connectivity of the ventral prefrontal cortex in late life depression. PLoS ONE 6, e22697 (2011). CAS PubMed PubMed Central Article Google Scholar Abi Zeid Daou, M., Boyd, B. D., Donahue, M. J., Albert, K. & Taylor, W. D. Anterior-posterior gradient differences in lobar and cingulate cortex cerebral blood flow in late-life depression. J. Psychiatr. Res. 97, 1–7 (2018). PubMed Article Google Scholar Direk, N. et al. Cerebral hemodynamics and incident depression: the Rotterdam study. Biol. Psychiatry 72, 318–323 (2012). PubMed Article Google Scholar Brickman, A. M. et al. Reduction in cerebral blood flow in areas appearing as white matter hyperintensities on magnetic resonance imaging. Psychiatry Res. 172, 117–120 (2009). PubMed PubMed Central Article Google Scholar van Sloten, T. T. et al. Endothelial dysfunction is associated with a greater depressive symptom score in a general elderly population: the Hoorn Study. Psychol. Med. 44, 1403–1416 (2014). PubMed Article Google Scholar Liao, W. et al. Cerebral blood flow changes in remitted early- and late-onset depression patients. Oncotarget 8, 76214–76222 (2017). PubMed PubMed Central Google Scholar van Agtmaal, M. J. M., Houben, A., Pouwer, F., Stehouwer, C. D. A. & Schram, M. T. Association of microvascular dysfunction with late-life depression: a systematic review and meta-analysis. JAMA Psychiatry 74, 729–739 (2017). PubMed PubMed Central Article Google Scholar Smagula, S. F. et al. Immunological biomarkers associated with brain structure and executive function in late-life depression: exploratory pilot study. Int. J. Geriatr. Psychiatry 32, 692–699 (2017). PubMed Article Google Scholar Almeida, O. P. et al. Homocysteine and depression in later life. Arch. Gen. Psychiatry 65, 1286–1294 (2008). CAS PubMed Article Google Scholar Satizabal, C. L., Zhu, Y. C., Mazoyer, B., Dufouil, C. & Tzourio, C. Circulating IL-6 and CRP are associated with MRI findings in the elderly: the 3C-Dijon Study. Neurology 78, 720–727 (2012). CAS PubMed Article Google Scholar Dorr, A. et al. Amyloid-beta-dependent compromise of microvascular structure and function in a model of Alzheimer’s disease. Brain 135(Pt 10), 3039–3050 (2012). PubMed Article Google Scholar Alexopoulos, G. S. & Morimoto, S. S. The inflammation hypothesis in geriatric depression. Int. J. Geriatr. Psychiatry 26, 1109–1118 (2011). PubMed PubMed Central Google Scholar Gruver, A. L., Hudson, L. L. & Sempowski, G. D. Immunosenescence of ageing. J. Pathol. 211, 144–156 (2007). CAS PubMed PubMed Central Article Google Scholar Dilger, R. N. & Johnson, R. W. Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system. J. Leukoc. Biol. 84, 932–939 (2008). CAS PubMed PubMed Central Article Google Scholar Lucin, K. M. & Wyss-Coray, T. Immune activation in brain aging and neurodegeneration: too much or too little? Neuron 64, 110–122 (2009). CAS PubMed PubMed Central Article Google Scholar Dantzer, R., O’Connor, J. C., Lawson, M. A. & Kelley, K. W. Inflammation-associated depression: from serotonin to kynurenine. Psychoneuroendocrinology 36, 426–436 (2011). CAS PubMed Article Google Scholar Haroon, E. et al. Conceptual convergence: increased inflammation is associated with increased basal ganglia glutamate in patients with major depression. Mol. Psychiatry 21, 1351–1357 (2016). CAS PubMed PubMed Central Article Google Scholar Haroon, E. et al. IFN-alpha-induced cortical and subcortical glutamate changes assessed by magnetic resonance spectroscopy. Neuropsychopharmacology 39, 1777–1785 (2014). CAS PubMed PubMed Central Article Google Scholar Haroon, E. et al. Age-related increases in basal ganglia glutamate are associated with TNF, reduced motivation and decreased psychomotor speed during IFN-alpha treatment: preliminary findings. Brain Behav. Immun. 46, 17–22 (2015). CAS PubMed Article Google Scholar Kiecolt-Glaser, J. K., Derry, H. M. & Fagundes, C. P. Inflammation: depression fans the flames and feasts on the heat. Am. J. Psychiatry 172, 1075–1091 (2015). PubMed PubMed Central Article Google Scholar Slavich, G. M. & Irwin, M. R. From stress to inflammation and major depressive disorder: a social signal transduction theory of depression. Psychol. Bull. 140, 774–815 (2014). PubMed PubMed Central Article Google Scholar Setiawan, E. et al. Association of translocator protein total distribution volume with duration of untreated major depressive disorder: a cross-sectional study. Lancet Psychiatry 5, 339–347 (2018). PubMed Article Google Scholar Thomas, A. J., Ferrier, I. N., Kalaria, R. N., Davis, S. & O’Brien, J. T. Cell adhesion molecule expression in the dorsolateral prefrontal cortex and anterior cingulate cortex in major depression in the elderly. Br. J. Psychiatry. 181, 129–134 (2002). PubMed Article Google Scholar Baune B. T., et al. The interleukin 1 beta (IL1B) gene is associated with failure to achieve remission and impaired emotion processing in major depression. Biol. Psychiatry 67, 543–549 (2010). CAS PubMed Article Google Scholar Capuron, L. et al. Anterior cingulate activation and error processing during interferon-alpha treatment. Biol. Psychiatry 58, 190–196 (2005). CAS PubMed PubMed Central Article Google Scholar Alexopoulos, G. S., Gunning-Dixon, F. M., Latoussakis, V., Kanellopoulos, D. & Murphy, C. F. Anterior cingulate dysfunction in geriatric depression. Int. J. Geriatr. Psychiatry 23, 347–355 (2008). PubMed Article Google Scholar Harrison, N. A. et al. Inflammation causes mood changes through alterations in subgenual cingulate activity and mesolimbic connectivity. Biol. Psychiatry 66, 407–414 (2009). PubMed PubMed Central Article Google Scholar Gaarden, T. L. et al. Exploration of 27 plasma immune markers: a cross-sectional comparison of 64 old psychiatric inpatients having unipolar major depression and 18 non-depressed old persons. BMC Geriatr. 18, 149 (2018). PubMed PubMed Central Article CAS Google Scholar Gimeno, D. et al. Associations of C-reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study. Psychol. Med. 39, 413–423 (2009). CAS PubMed Article Google Scholar Kohler, C. A. et al. Peripheral cytokine and chemokine alterations in depression: a meta-analysis of 82 studies. Acta Psychiatr. Scand. 135, 373–387 (2017). CAS PubMed Article Google Scholar Lindqvist, D. et al. Interleukin-6 is elevated in the cerebrospinal fluid of suicide attempters and related to symptom severity. Biol. Psychiatry 66, 287–292 (2009). CAS PubMed Article Google Scholar Milaneschi, Y. et al. Interleukin-1 receptor antagonist and incident depressive symptoms over 6 years in older persons: the InCHIANTI study. Biol. Psychiatry 65, 973–978 (2009). CAS PubMed Article Google Scholar Kohler, C. A. et al. Peripheral alterations in cytokine and chemokine levels after antidepressant drug treatment for major depressive disorder: systematic review and meta-analysis. Mol. Neurobiol. 55, 4195–4206 (2018). CAS PubMed Google Scholar Apostolakis, S., Vogiatzi, K., Krambovitis, E. & Spandidos, D. A. IL-1 cytokines in cardiovascular disease: diagnostic, prognostic and therapeutic implications. Cardiovasc Hematol. Agents Med. Chem. 6, 150–158 (2008). CAS PubMed Article Google Scholar Sparkman, N. L. & Johnson, R. W. Neuroinflammation associated with aging sensitizes the brain to the effects of infection or stress. Neuroimmunomodulation 15, 323–330 (2008). CAS PubMed Article Google Scholar Irwin, M. R. & Cole, S. W. Reciprocal regulation of the neural and innate immune systems. Nat. Rev. Immunol. 11, 625–632 (2011). CAS PubMed PubMed Central Article Google Scholar Mahgoub, N. & Alexopoulos, G. S. The amyloid hypothesis: is there a role for anti-amyloid treatment in late-life depression? Am. J. Geriatr. Psychiatry. 24, 239–247 (2016). PubMed PubMed Central Article Google Scholar Yasuno, F. et al. High amyloid-beta deposition related to depressive symptoms in older individuals with normal cognition: a pilot study. Int. J. Geriatr. Psychiatry 31, 920–928 (2016). PubMed Article Google Scholar Donovan, N. J. et al. Longitudinal association of amyloid beta and anxious-depressive symptoms in cognitively normal older adults. Am. J. Psychiatry 175, 530–537 (2018). PubMed PubMed Central Article Google Scholar Wu, K. Y. et al. Increased brain amyloid deposition in patients with a lifetime history of major depression: evidenced on 18F-florbetapir (AV-45/Amyvid) positron emission tomography. Eur. J. Nucl. Med. Mol. Imaging 41, 714–722 (2014). CAS PubMed Article Google Scholar Gallagher, D., Kiss, A., Lanctot, K. & Herrmann, N. Depression and risk of alzheimer dementia: a longitudinal analysis to determine predictors of increased risk among older adults with depression. Am. J. Geriatr. Psychiatry 26, 819–827 (2018). PubMed PubMed Central Article Google Scholar Chung, J. K. et al. Lifetime history of depression predicts increased amyloid-beta accumulation in patients with mild cognitive impairment. J. Alzheimers Dis. 45, 907–919 (2015). CAS PubMed Article PubMed Central Google Scholar Rapp, M. A. et al. Increased hippocampal plaques and tangles in patients with Alzheimer disease with a lifetime history of major depression. Arch. Gen. Psychiatry 63, 161–167 (2006). PubMed Article Google Scholar Sun, X. et al. Amyloid-associated depression: a prodromal depression of Alzheimer disease? Arch. Gen. Psychiatry 65, 542–550 (2008). CAS PubMed PubMed Central Article Google Scholar Sheline, Y. I. et al. An antidepressant decreases CSF Abeta production in healthy individuals and in transgenic AD mice. Sci. Transl. Med. 6, 236re234 (2014). Google Scholar Cirrito, J. R. et al. Serotonin signaling is associated with lower amyloid-beta levels and plaques in transgenic mice and humans. Proc. Natl Acad. Sci. USA 108, 14968–14973 (2011). CAS PubMed Article PubMed Central Google Scholar Bartels, C., Wagner, M., Wolfsgruber, S., Ehrenreich, H. & Schneider, A. Impact of SSRI therapy on risk of conversion from mild cognitive impairment to Alzheimer’s dementia in individuals with previous depression. Am. J. Psychiatry 175, 232–241 (2018). PubMed Article Google Scholar De Winter, F. L. et al. No association of lower hippocampal volume with Alzheimer’s disease pathology in late-life depression. Am. J. Psychiatry 174, 237–245 (2017). PubMed Article Google Scholar Madsen, K. et al. Lack of association between prior depressive episodes and cerebral [11C]PiB binding. Neurobiol. Aging 33, 2334–2342 (2012). CAS PubMed Article Google Scholar O’Brien, J. et al. Cognitive impairment in depression is not associated with neuropathologic evidence of increased vascular or Alzheimer-type pathology. Biol. Psychiatry 49, 130–136 (2001). PubMed Article Google Scholar Hendricksen, M., Thomas, A. J., Ferrier, I. N., Ince, P. & O’Brien, J. T. Neuropathological study of the dorsal raphe nuclei in late-life depression and Alzheimer’s disease with and without depression. Am. J. Psychiatry 161, 1096–1102 (2004). PubMed Article Google Scholar McCutcheon, S. T. et al. Clinicopathological correlates of depression in early Alzheimer’s disease in the NACC. Int. J. Geriatr. Psychiatry 31, 1301–1311 (2016). PubMed PubMed Central Article Google Scholar Brown, E. E., Iwata, Y., Chung, J. K., Gerretsen, P. & Graff-Guerrero, A. Tau in late-life depression: a systematic review and meta-analysis. J. Alzheimers Dis. 54, 615–633 (2016). CAS PubMed Article Google Scholar Schaakxs, R. et al. Associations between age and the course of major depressive disorder: a 2-year longitudinal cohort study. Lancet Psychiatry 5, 581–590 (2018). PubMed Article Google Scholar Cipriani, A. et al. Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. Lancet 391, 1357–1366 (2018). CAS PubMed PubMed Central Article Google Scholar Tedeschini, E. et al. Efficacy of antidepressants for late-life depression: a meta-analysis and meta-regression of placebo-controlled randomized trials. J. Clin. Psychiatry 72, 1660–1668 (2011). CAS PubMed Article Google Scholar Kok, R. M., Nolen, W. A. & Heeren, T. J. Efficacy of treatment in older depressed patients: a systematic review and meta-analysis of double-blind randomized controlled trials with antidepressants. J. Affect. Disord. 141, 103–115 (2012). CAS PubMed Article Google Scholar Kok, R. M. & Reynolds, C. F. 3rd Management of depression in older adults: a review. JAMA 317, 2114–2122 (2017). CAS PubMed Article Google Scholar Cooper, C. et al. A systematic review of treatments for refractory depression in older people. Am. J. Psychiatry 168, 681–688 (2011). PubMed Article Google Scholar Lenze, E. J. et al. Efficacy, safety, and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in late life: a randomised, double-blind, placebo-controlled trial. Lancet 386, 2404–2412 (2015). CAS PubMed PubMed Central Article Google Scholar Lavretsky, H. et al. Citalopram, methylphenidate, or their combination in geriatric depression: a randomized, double-blind, placebo-controlled trial. Am. J. Psychiatry 172, 561–569 (2015). PubMed PubMed Central Article Google Scholar Reynolds, C. F. 3rd et al. Maintenance treatment of depression in old age: a randomized, double-blind, placebo-controlled evaluation of the efficacy and safety of donepezil combined with antidepressant pharmacotherapy. Arch. Gen. Psychiatry 68, 51–60 (2011). PubMed PubMed Central Article Google Scholar Devanand, D. P. et al. Donepezil treatment in patients with depression and cognitive impairment on stable antidepressant treatment: a randomized controlled trial. Am. J. Geriatr. Psychiatry 26, 1050–1060 (2018). PubMed PubMed Central Article Google Scholar Mitchell, A. J. & Subramaniam, H. Prognosis of depression in old age compared to middle age: a systematic review of comparative studies. Am. J. Psychiatry 162, 1588–1601 (2005). PubMed Article Google Scholar Kok, R. M., Heeren, T. J. & Nolen, W. A. Continuing treatment of depression in the elderly: a systematic review and meta-analysis of double-blinded randomized controlled trials with antidepressants. Am. J. Geriatr. Psychiatry 19, 249–255 (2011). PubMed Article Google Scholar Reynolds, C. F. 3rd et al. Maintenance treatment of major depression in old age. New Engl. J. Med. 354, 1130–1138 (2006). CAS PubMed Article Google Scholar Reynolds, C. F. 3rd et al. Nortriptyline and interpersonal psychotherapy as maintenance therapies for recurrent major depression: a randomized controlled trial in patients older than 59 years. JAMA 281, 39–45 (1999). CAS PubMed Article Google Scholar Borges, S. et al. Review of maintenance trials for major depressive disorder: a 25-year perspective from the US Food and Drug Administration. J. Clin. Psychiatry 75, 205–214 (2014). PubMed Article Google Scholar Deng, Y. et al. Predictors of recurrence in remitted late-life depression. Depress. Anxiety 35, 658–667 (2018). PubMed PubMed Central Article Google Scholar Alexopoulos, G. S., Katz, I. R., Reynolds, C. F., 3rd, Carpenter, D., Docherty, J. P. The expert consensus guideline series. Pharmacotherapy of depressive disorders in older patients. Postgraduate Med. 110, 1–86 (2001). Kiosses, D. N. & Alexopoulos, G. S. The prognostic significance of subsyndromal symptoms emerging after remission of late-life depression. Psychol. Med. 43, 341–350 (2013). CAS PubMed Article Google Scholar Hedayati, S. S. et al. Effect of sertraline on depressive symptoms in patients with chronic kidney disease without dialysis dependence: the CAST randomized clinical trial. JAMA 318, 1876–1890 (2017). CAS PubMed PubMed Central Article Google Scholar Mulick, A. et al. Does depression treatment improve the survival of depressed patients with cancer? A long-term follow-up of participants in the SMaRT Oncology-2 and 3 trials. Lancet Psychiatry 5, 321–326 (2018). PubMed Article Google Scholar Pizzi, C. et al. Meta-analysis of selective serotonin reuptake inhibitors in patients with depression and coronary heart disease. Am. J. Cardiol. 107, 972–979 (2011). CAS PubMed Article Google Scholar Glassman, A. H. et al. Sertraline treatment of major depression in patients with acute MI or unstable angina. JAMA 288, 701–709 (2002). CAS PubMed Article Google Scholar Honig, A. et al. Treatment of post-myocardial infarction depressive disorder: a randomized, placebo-controlled trial with mirtazapine. Psychosom. Med. 69, 606–613 (2007). CAS PubMed Article Google Scholar Lesperance, F. et al. Effects of citalopram and interpersonal psychotherapy on depression in patients with coronary artery disease: the Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy (CREATE) trial. JAMA 297, 367–379 (2007). CAS PubMed Article Google Scholar Kim, J. M. et al. Effect of escitalopram vs placebo treatment for depression on long-term cardiac outcomes in patients with acute coronary syndrome: a randomized clinical trial. JAMAama 320, 350–358 (2018). CAS Article Google Scholar Nelson, J. C. & Devanand, D. P. A systematic review and meta-analysis of placebo-controlled antidepressant studies in people with depression and dementia. J. Am. Geriatr. Soc. 59, 577–585 (2011). PubMed Article Google Scholar Kessing, L. V., Sondergard, L., Forman, J. L. & Andersen, P. K. Lithium treatment and risk of dementia. Arch. Gen. Psychiatry 65, 1331–1335 (2008). PubMed Article Google Scholar Zivin, K. & Kales, H. C. Adherence to depression treatment in older adults: a narrative review. Drugs Aging 25, 559–571 (2008). PubMed Article Google Scholar Spaans, H. P. et al. Speed of remission in elderly patients with depression: electroconvulsive therapy v. medication. Br. J. Psychiatry 206, 67–71 (2015). PubMed Article Google Scholar Taylor, W. D. Clinical practice. Depression in the elderly. New Engl. J. Med. 371, 1228–1236 (2014). CAS PubMed Article Google Scholar Slade, E. P., Jahn, D. R., Regenold, W. T. & Case, B. G. Association of electroconvulsive therapy with psychiatric readmissions in US hospitals. JAMA psychiatry 74, 798–804 (2017). PubMed PubMed Central Article Google Scholar Kerner, N. & Prudic, J. Current electroconvulsive therapy practice and research in the geriatric population. Neuropsychiatry 4, 33–54 (2014). PubMed PubMed Central Article Google Scholar Tor, P. C. et al. A systematic review and meta-analysis of brief versus ultrabrief right unilateral electroconvulsive therapy for depression. J. Clin. Psychiatry 76, e1092–e1098 (2015). PubMed Article Google Scholar Kellner, C. H. et al. Right unilateral ultrabrief pulse ECT in geriatric depression: phase 1 of the PRIDE study. Am. J. Psychiatry 173, 1101–1109 (2016). PubMed Article PubMed Central Google Scholar Kiosses, D. N., Leon, A. C. & Arean, P. A. Psychosocial interventions for late-life major depression: evidence-based treatments, predictors of treatment outcomes, and moderators of treatment effects. Psychiatr. Clin. North Am. 34, 377–401 (2011). PubMed PubMed Central Article Google Scholar Pinquart, M., Duberstein, P. R. & Lyness, J. M. Treatments for later-life depressive conditions: a meta-analytic comparison of pharmacotherapy and psychotherapy. Am. J. Psychiatry 163, 1493–1501 (2006). PubMed Article Google Scholar Arean, P. A. et al. Problem-solving therapy and supportive therapy in older adults with major depression and executive dysfunction. Am. J. Psychiatry 167, 1391–1398 (2010). PubMed PubMed Central Article Google Scholar Alexopoulos, G. S. et al. Problem-solving therapy and supportive therapy in older adults with major depression and executive dysfunction: effect on disability. Arch. Gen. Psychiatry 68, 33–41 (2011). PubMed PubMed Central Article Google Scholar Bella, R. et al. Clinical presentation and outcome of geriatric depression in subcortical ischemic vascular disease. Gerontology 56, 298–302 (2010). CAS PubMed Article Google Scholar Alexopoulos, G. S. et al. Two behavioral interventions for patients with major depression and severe COPD. Am. J. Geriatr. Psychiatry 24, 964–974 (2016). PubMed PubMed Central Article Google Scholar Alexopoulos, G. S. et al. Two interventions for patients with major depression and severe chronic obstructive pulmonary disease: impact on dyspnea-related disability. Am. J. Geriatr. Psychiatry 26, 162–171 (2018). PubMed Article Google Scholar Alexopoulos, G. S. et al. Personalised intervention for people with depression and severe COPD. Br. J. Psychiatry 202, 235–236 (2013). PubMed PubMed Central Article Google Scholar Alexopoulos, G. S. et al. Clinical case management versus case management with problem-solving therapy in low-income, disabled elders with major depression: a randomized clinical trial. Am. J. Geriatr. Psychiatry 24, 50–59 (2016). PubMed Article Google Scholar NAS. Standrards for Psychosocial Interventions. (NAS, Washington, D.C, 2015). Google Scholar Alexopoulos, G. S. & Arean, P. A model for streamlining psychotherapy in the RDoC era: the example of ‘Engage’. Mol. Psychiatry 19, 14–19 (2014). CAS PubMed Article Google Scholar Alexopoulos, G. S. et al. Comparing engage with PST in late-life major depression: a preliminary report. Am. J. Geriatr. Psychiatry 23, 506–513 (2015). PubMed Article Google Scholar Alexopoulos, G. S. et al. “Engage” therapy: behavioral activation and improvement of late-life major depression. Am. J. Geriatr. Psychiatry 24, 320–326 (2016). PubMed Article Google Scholar Alexopoulos, G. S. et al. “Engage” therapy: prediction of change of late-life major depression. J. Affect. Disord. 221, 192–197 (2017). PubMed PubMed Central Article Google Scholar Willner, P., Hale, A. S. & Argyropoulos, S. Dopaminergic mechanism of antidepressant action in depressed patients. J. Affect. Disord. 86, 37–45 (2005). CAS PubMed Article Google Scholar Barone, P. et al. Pramipexole for the treatment of depressive symptoms in patients with Parkinson’s disease: a randomised, double-blind, placebo-controlled trial. Lancet Neurol. 9, 573–580 (2010). CAS PubMed Article Google Scholar Inoue, T. et al. Pramipexole for stage 2 treatment-resistant major depression: an open study. Prog. Neuropsychopharmacol. Biol. Psychiatry 34, 1446–1449 (2010). CAS PubMed Article Google Scholar Hori, H. & Kunugi, H. The efficacy of pramipexole, a dopamine receptor agonist, as an adjunctive treatment in treatment-resistant depression: an open-label trial. Sci. World J. 2012, 372474 (2012). Article CAS Google Scholar Corrigan, M. H., Denahan, A. Q., Wright, C. E., Ragual, R. J. & Evans, D. L. Comparison of pramipexole, fluoxetine, and placebo in patients with major depression. Depress. Anxiety 11, 58–65 (2000). CAS PubMed Article Google Scholar Anguera, J. A., Gunning, F. M. & Arean, P. A. Improving late life depression and cognitive control through the use of therapeutic video game technology: A proof-of-concept randomized trial. Depress. Anxiety 34, 508–517 (2017). PubMed PubMed Central Article Google Scholar Morimoto, S. S. et al. Neuroplasticity-based computerized cognitive remediation for treatment-resistant geriatric depression. Nat. Commun. 5, 4579 (2014). CAS PubMed Article Google Scholar Dubin, M. J., Liston, C., Avissar, M. A., Ilieva, I. & Gunning, F. M. Network-guided transcranial magnetic stimulation for depression. Curr. Behav. Neurosci. Rep. 4, 70–77 (2017). PubMed PubMed Central Article Google Scholar Kaster, T. S. et al. Efficacy, tolerability, and cognitive effects of deep transcranial magnetic stimulation for late-life depression: a prospective randomized controlled trial. Neuropsychopharmacology 43, 2231–2238 (2018). PubMed Article PubMed Central Google Scholar Jorge, R. E., Moser, D. J., Acion, L. & Robinson, R. G. Treatment of vascular depression using repetitive transcranial magnetic stimulation. Arch. Gen. Psychiatry 65, 268–276 (2008). PubMed Article Google Scholar Muntner, P. et al. Potential U.S. population impact of the 2017 ACC/AHA high blood pressure guideline. J. Am. Coll. Cardiol. 71, 109–118 (2018). PubMed Article Google Scholar Dupuis, F., Atkinson, J., Liminana, P. & Chillon, J. M. Captopril improves cerebrovascular structure and function in old hypertensive rats. Br. J. Pharmacol. 144, 349–356 (2005). CAS PubMed PubMed Central Article Google Scholar Morimoto, S., Maki, K., Aota, Y., Sakuma, T. & Iwasaka, T. Beneficial effects of combination therapy with angiotensin II receptor blocker and angiotensin-converting enzyme inhibitor on vascular endothelial function. Hypertens. Res. 31, 1603–1610 (2008). CAS PubMed Article Google Scholar Hajjar, I. et al. Effect of antihypertensive therapy on cognitive function in early executive cognitive impairment: a double-blind randomized clinical trial. Arch. Intern. Med. 172, 442–444 (2012). PubMed PubMed Central Article Google Scholar Moriwaki, H. et al. Losartan, an angiotensin II (AT1) receptor antagonist, preserves cerebral blood flow in hypertensive patients with a history of stroke. J. Hum. Hypertens. 18, 693–699 (2004). CAS PubMed Article Google Scholar Wilms, H., Rosenstiel, P., Unger, T., Deuschl, G. & Lucius, R. Neuroprotection with angiotensin receptor antagonists: a review of the evidence and potential mechanisms. Am. J. Cardiovasc. Drug. 5, 245–253 (2005). CAS Article Google Scholar Nagata, R., Kawabe, K. & Ikeda, K. Olmesartan, an angiotensin II receptor blocker, restores cerebral hypoperfusion in elderly patients with hypertension. J. Stroke Cereb. Dis. 19, 236–240 (2010). Article Google Scholar Pavlatou, M. G. et al. Chronic administration of an angiotensin II receptor antagonist resets the hypothalamic-pituitary-adrenal (HPA) axis and improves the affect of patients with diabetes mellitus type 2: preliminary results. Stress 11, 62–72 (2008). CAS PubMed Article Google Scholar Taragano, F. E., Allegri, R., Vicario, A., Bagnatti, P. & Lyketsos, C. G. A double blind, randomized clinical trial assessing the efficacy and safety of augmenting standard antidepressant therapy with nimodipine in the treatment of ‘vascular depression’. Int. J. Geriatr. Psychiatry 16, 254–260 (2001). CAS PubMed Article Google Scholar Taragano, F. E., Bagnatti, P. & Allegri, R. F. A double-blind, randomized clinical trial to assess the augmentation with nimodipine of antidepressant therapy in the treatment of “vascular depression”. Int. Psychogeriatr. 17, 487–498 (2005). CAS PubMed Article Google Scholar Ried, L. D., Tueth, M. J., Handberg, E., Kupfer, S. & Pepine, C. J. A Study of Antihypertensive Drugs and Depressive Symptoms (SADD-Sx) in patients treated with a calcium antagonist versus an atenolol hypertension Treatment Strategy in the International Verapamil SR-Trandolapril Study (INVEST). Psychosom. Med. 67, 398–406 (2005). CAS PubMed Article Google Scholar Parsaik, A. K. et al. Statins use and risk of depression: a systematic review and meta-analysis. J. Affect. Disord. 160, 62–67 (2014). CAS PubMed Article Google Scholar Vogelzangs, N. et al. Inflammatory and metabolic dysregulation and the 2-year course of depressive disorders in antidepressant users. Neuropsychopharmacology 39, 1624–1634 (2014). CAS PubMed PubMed Central Article Google Scholar Uher, R. et al. An inflammatory biomarker as a differential predictor of outcome of depression treatment with escitalopram and nortriptyline. Am. J. Psychiatry 171, 1278–1286 (2014). Article PubMed Google Scholar Kohler, O. et al. Effect of anti-inflammatory treatment on depression, depressive symptoms, and adverse effects: a systematic review and meta-analysis of randomized clinical trials. JAMA Psychiatry 71, 1381–1391 (2014). PubMed Article Google Scholar Raison, C. L. et al. A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers. JAMA Psychiatry 70, 31–41 (2013). CAS PubMed PubMed Central Article Google Scholar Raison, C. L. The promise and limitations of anti-inflammatory agents for the treatment of major depressive disorder. Curr. Top. Behav. Neurosci. 31, 287–302 (2017). CAS PubMed Article Google Scholar Which type of therapy has been used widely with those suffering from an anxiety disorder in old age?Cognitive behavioral therapy (CBT) has been shown to be effective for a wide variety of mental health disorders,1 including anxiety disorders. CBT has also been associated with improvements in quality of life in anxiety patients.
Which is the best example of mental health parity?Which is the BEST example of mental health parity? Your insurance covers medical and mental illnesses equally.
When seeking clear and convincing proof of mental illness the US Supreme Court has ruled that there must be?When seeking clear and convincing proof, the U.S. Supreme Court has ruled that there must be: 75 percent certainty.
What behavior suggests that a child has autism spectrum disorder?People with ASD often have problems with social communication and interaction, and restricted or repetitive behaviors or interests. People with ASD may also have different ways of learning, moving, or paying attention. It is important to note that some people without ASD might also have some of these symptoms.
|
Which therapy is used to treat depression in the elderly after other therapy attempts fail?
zusammenhängende Posts
Urheberrechte © © 2024 WIKIFI Inc.
